TY - JOUR
T1 - PfEMP1 and var genes - Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity
AU - Hviid, Lars
AU - Jensen, Anja R
AU - Deitsch, Kirk W
N1 - Copyright © 2024. Published by Elsevier Ltd.
PY - 2024
Y1 - 2024
N2 - The most severe form of malaria, caused by infection with Plasmodium falciparum parasites, continues to be an important cause of human suffering and poverty. The P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens, which mediates the adhesion of infected erythrocytes to the vascular endothelium in various tissues and organs, is a central component of the pathogenesis of the disease and a key target of the acquired immune response to malaria. Much new knowledge has accumulated since we published a systematic overview of the PfEMP1 family almost ten years ago. In this chapter, we therefore aim to summarize research progress since 2015 on the structure, function, regulation etc. of this key protein family of arguably the most important human parasite. Recent insights regarding PfEMP1-specific immune responses and PfEMP1-specific vaccination against malaria, as well as an outlook for the coming years are also covered.
AB - The most severe form of malaria, caused by infection with Plasmodium falciparum parasites, continues to be an important cause of human suffering and poverty. The P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens, which mediates the adhesion of infected erythrocytes to the vascular endothelium in various tissues and organs, is a central component of the pathogenesis of the disease and a key target of the acquired immune response to malaria. Much new knowledge has accumulated since we published a systematic overview of the PfEMP1 family almost ten years ago. In this chapter, we therefore aim to summarize research progress since 2015 on the structure, function, regulation etc. of this key protein family of arguably the most important human parasite. Recent insights regarding PfEMP1-specific immune responses and PfEMP1-specific vaccination against malaria, as well as an outlook for the coming years are also covered.
KW - Malaria, Falciparum/immunology
KW - Plasmodium falciparum/immunology
KW - Humans
KW - Protozoan Proteins/genetics
KW - Animals
UR - http://www.scopus.com/inward/record.url?scp=85188725553&partnerID=8YFLogxK
U2 - 10.1016/bs.apar.2024.02.001
DO - 10.1016/bs.apar.2024.02.001
M3 - Review
C2 - 39095112
SN - 0065-308X
VL - 125
SP - 53
EP - 103
JO - Advances in Parasitology
JF - Advances in Parasitology
ER -