Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

PfEMP1 - A Parasite Protein Family of Key Importance in Plasmodium falciparum Malaria Immunity and Pathogenesis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. No sweet deal: the antibody-mediated immune response to malaria

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Frequency of Electrocardiographic Alterations and Pericardial Effusion in Patients With Uncomplicated Malaria

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. PfEMP1-Specific Immunoglobulin G Reactivity Among Beninese Pregnant Women With Sickle Cell Trait

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Heart failure associated with imported malaria: a nationwide Danish cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Plasmodium falciparum causes the most severe form of malaria and is responsible for essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes infected by mature P. falciparum parasites can lead to circulatory disturbances and inflammation, and is thought to be a central element in the pathogenesis of the disease. It is mediated by the interaction of parasite ligands on the erythrocyte surface and a range of host receptor molecules in many organs and tissues. Among several proteins and protein families implicated in this process, the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of high-molecular weight and highly variable antigens appears to be the most prominent. In this chapter, we aim to provide a systematic overview of the current knowledge about these proteins, their structure, their function, how they are presented on the erythrocyte surface, and how the var genes encoding them are regulated. The role of PfEMP1 in the pathogenesis of malaria, PfEMP1-specific immune responses, and the prospect of PfEMP1-specific vaccination against malaria are also covered briefly.

OriginalsprogEngelsk
BogserieAdvances in Parasitology
Vol/bind88
Sider (fra-til)51-84
Antal sider34
ISSN0065-308X
DOI
StatusUdgivet - apr. 2015

ID: 45787622