PET/CT in the diagnosis of inflammatory bowel disease in pediatric patients: a review

Mikkel Malham; Søren Hess; Rasmus G Nielsen; Steffen Husby; Poul Flemming Høilund-Carlsen

PET/CT in the diagnosis of inflammatory bowel disease in pediatric patients: a review

Mikkel Malham, Søren Hess, Rasmus G Nielsen, Steffen Husby, Poul Flemming Høilund-Carlsen

Abstract

The literature on positron emission tomography and computed tomography using 18fluoro-deoxyglusose (FDG-PET/CT) in the diagnosis of pediatric inflammatory bowel disease (IBD) is presented. Only five papers representing independent studies were identified and included in this review. Of these, two studies dealt with both stand-alone FDG-PET and FDG-PET/CT, while three were about stand-alone FDG-PET only. No studies could be found that focused on FDG-PET/CT only. The five studies comprised analysis of a total 181 pediatric patients (0-18 years of age). They unanimously indicated that FDG-PET/CT is a versatile method with a diagnostic high sensitivity ranging from 70% to 97%. In conclusion, the pediatric literature on FGD-PET/CT’s role in the diagnosis of IBD is very limited. Prospective studies of well characterized populations are needed in order to validate this novel imaging modality in pediatric IBD.

Keywords: Inflammatory bowel disease, ulcerative colitis, Crohn’s disease, positron-emission tomography and computed tomography

Originalsprog	Engelsk
Tidsskrift	American Journal of Nuclear Medicine and Molecular Imaging
Vol/bind	4
Udgave nummer	3
Sider (fra-til)	225-30
Antal sider	6
ISSN	2160-8407
Status	Udgivet - 2014
Udgivet eksternt	Ja

Citationsformater

@article{c48d5c24861248a48cd47acdca5b6482,

title = "PET/CT in the diagnosis of inflammatory bowel disease in pediatric patients: a review",

abstract = "The literature on positron emission tomography and computed tomography using 18fluoro-deoxyglusose (FDG-PET/CT) in the diagnosis of pediatric inflammatory bowel disease (IBD) is presented. Only five papers representing independent studies were identified and included in this review. Of these, two studies dealt with both stand-alone FDG-PET and FDG-PET/CT, while three were about stand-alone FDG-PET only. No studies could be found that focused on FDG-PET/CT only. The five studies comprised analysis of a total 181 pediatric patients (0-18 years of age). They unanimously indicated that FDG-PET/CT is a versatile method with a diagnostic high sensitivity ranging from 70% to 97%. In conclusion, the pediatric literature on FGD-PET/CT{\textquoteright}s role in the diagnosis of IBD is very limited. Prospective studies of well characterized populations are needed in order to validate this novel imaging modality in pediatric IBD.Keywords: Inflammatory bowel disease, ulcerative colitis, Crohn{\textquoteright}s disease, positron-emission tomography and computed tomography",

author = "Mikkel Malham and S{\o}ren Hess and Nielsen, {Rasmus G} and Steffen Husby and H{\o}ilund-Carlsen, {Poul Flemming}",

year = "2014",

language = "English",

volume = "4",

pages = "225--30",

journal = "American Journal of Nuclear Medicine and Molecular Imaging",

issn = "2160-8407",

publisher = "E-Century Publishing Corporation",

number = "3",

}

TY - JOUR

T1 - PET/CT in the diagnosis of inflammatory bowel disease in pediatric patients

T2 - a review

AU - Malham, Mikkel

AU - Hess, Søren

AU - Nielsen, Rasmus G

AU - Husby, Steffen

AU - Høilund-Carlsen, Poul Flemming

PY - 2014

Y1 - 2014

N2 - The literature on positron emission tomography and computed tomography using 18fluoro-deoxyglusose (FDG-PET/CT) in the diagnosis of pediatric inflammatory bowel disease (IBD) is presented. Only five papers representing independent studies were identified and included in this review. Of these, two studies dealt with both stand-alone FDG-PET and FDG-PET/CT, while three were about stand-alone FDG-PET only. No studies could be found that focused on FDG-PET/CT only. The five studies comprised analysis of a total 181 pediatric patients (0-18 years of age). They unanimously indicated that FDG-PET/CT is a versatile method with a diagnostic high sensitivity ranging from 70% to 97%. In conclusion, the pediatric literature on FGD-PET/CT’s role in the diagnosis of IBD is very limited. Prospective studies of well characterized populations are needed in order to validate this novel imaging modality in pediatric IBD.Keywords: Inflammatory bowel disease, ulcerative colitis, Crohn’s disease, positron-emission tomography and computed tomography

AB - The literature on positron emission tomography and computed tomography using 18fluoro-deoxyglusose (FDG-PET/CT) in the diagnosis of pediatric inflammatory bowel disease (IBD) is presented. Only five papers representing independent studies were identified and included in this review. Of these, two studies dealt with both stand-alone FDG-PET and FDG-PET/CT, while three were about stand-alone FDG-PET only. No studies could be found that focused on FDG-PET/CT only. The five studies comprised analysis of a total 181 pediatric patients (0-18 years of age). They unanimously indicated that FDG-PET/CT is a versatile method with a diagnostic high sensitivity ranging from 70% to 97%. In conclusion, the pediatric literature on FGD-PET/CT’s role in the diagnosis of IBD is very limited. Prospective studies of well characterized populations are needed in order to validate this novel imaging modality in pediatric IBD.Keywords: Inflammatory bowel disease, ulcerative colitis, Crohn’s disease, positron-emission tomography and computed tomography

M3 - Review

C2 - 24795836

SN - 2160-8407

VL - 4

SP - 225

EP - 230

JO - American Journal of Nuclear Medicine and Molecular Imaging

JF - American Journal of Nuclear Medicine and Molecular Imaging

IS - 3

ER -