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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Perspectives on diabetes mortality as the result of residual confounding and reverse causality by common disease

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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Type 2 diabetes (T2D) is associated with major global health burdens, including 2 to 4 times increased rates of morbidity and mortality from cardiovascular disease. However, T2D remains an exclusion diagnosis in individuals with arbitrarily elevated blood-glucose levels. While it is well-established that diabetes is associated with an elevated risk of cardiovascular disease and cancer, it has recently been shown that heart failure and cancer may precede, and even contribute to, the development of T2D. In the present review, we have summarized these findings and discuss their potential implications for our understanding of the T2D disease entity, including its treatment and associated increased mortality. We suggest that the existence of a hitherto unrecognized distinct T2D subtype, secondary to heart failure and/or cancer, may substantially contribute to the excess mortality reported in T2D patients with mild disease. Treatment and clinical care of this subtype needs to be defined separately from the general T2D phenotype.

OriginalsprogEngelsk
TidsskriftDiabetes, Obesity and Metabolism
Vol/bind20
Udgave nummer6
Sider (fra-til)1342-1349
Antal sider8
ISSN1462-8902
DOI
StatusUdgivet - 1 jun. 2018

ID: 59277625