Personalization of Multi-electrode Setups in tCS/tES: Methods and Advantages

R. Salvador, M. C. Biagi, O. Puonti, M. Splittgerber, V. Moliadze, M. Siniatchkin, A. Thielscher, G. Ruffini

Abstract

Transcranial current stimulation (tCS or tES) protocols yield results that are highly variable across individuals. Part of this variability results from differences in the electric field (E-field) induced in subjects’ brains during stimulation. The E-field determines how neurons respond to stimulation, and it can be used as a proxy for predicting the concurrent effects of stimulation, like changes in cortical excitability, and, ultimately, its plastic effects. While the use of multichannel systems with small electrodes has provided a more precise tool for delivering tCS, individually variable anatomical parameters like the shape and thickness of tissues affect the E-field distribution for a specific electrode montage. Therefore, using the same montage parameters across subjects does not lead to the homogeneity of E-field amplitude over the desired targets. Here we describe a pipeline that leverages individualized head models combined with montage optimization algorithms to reduce the variability of the E-field distributions over subjects in tCS. We will describe the different steps of the pipeline – namely, MRI segmentation and head model creation, target specification, and montage optimization – and discuss their main advantages and limitations.
OriginalsprogEngelsk
TitelBrain and Human Body Modeling 2020: Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting
RedaktørerSergey N. Makarov, Gregory M. Noetscher, Aapo Nummenmaa
Antal sider17
UdgivelsesstedGewerbestrasse 11, 6330 Cham, Switzerland
ForlagSpringer International Publishing AG
Publikationsdato2020
Sider119-135
ISBN (Trykt)978-3-030-45622-1
ISBN (Elektronisk)978-3-030-45623-8
DOI
StatusUdgivet - 2020
Begivenhed41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Berlin, Tyskland
Varighed: 23 jul. 201927 jul. 2019

Konference

Konference41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Land/OmrådeTyskland
ByBerlin
Periode23/07/201927/07/2019

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