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Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study

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Nassan, Feiby L ; Coull, Brent A ; Gaskins, Audrey J ; Williams, Michelle A ; Skakkebaek, Niels E ; Ford, Jennifer B ; Ye, Xiaoyun ; Calafat, Antonia M ; Braun, Joseph M ; Hauser, Russ. / Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens : Results from the Environment And Reproductive Health (EARTH) Study. I: Environmental Health Perspectives. 2017 ; Bind 125, Nr. 8. s. 087012.

Bibtex

@article{0b8f652c597b46b3b9042803fbe4c119,
title = "Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study",
abstract = "BACKGROUND: Personal care products (PCPs) are exposure sources to phthalates and parabens; however, their contribution to men's exposure is understudied.OBJECTIVES: We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men.METHODS: In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a urine sample (2004-2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben. We estimated the covariate-adjusted percent change in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the resulting composite weighted PCP use.RESULTS: Four hundred men contributed 1,037 urine samples (mean of 3/man). The largest percent increase in monoethyl phthalate (MEP) was associated with use of cologne/perfume (83{\%}, p-value<0.01) and deodorant (74{\%}, p-value<0.01). In contrast, the largest percent increase for parabens was associated with the use of suntan/sunblock lotion (66-156{\%}) and hand/body lotion (79-147{\%}). Increases in MEP and parabens were generally greater with PCP use within 6 h of urine collection. A subset of 10 PCPs that were used within 6 h of urine collection contributed to at least 70{\%} of the weighted score and predicted a 254-1,333{\%} increase in MEP and parabens concentrations. Associations between PCP use and concentrations of the other phthalate metabolites were not statistically significant.CONCLUSIONS: We identified 10 PCPs of relevance and demonstrated that their use within 6 h of urine collection strongly predicted MEP and paraben urinary concentrations. https://doi.org/10.1289/EHP1374.",
keywords = "Adult, Cosmetics, Environmental Exposure, Hazardous Substances, Humans, Male, Parabens, Phthalic Acids, Journal Article",
author = "Nassan, {Feiby L} and Coull, {Brent A} and Gaskins, {Audrey J} and Williams, {Michelle A} and Skakkebaek, {Niels E} and Ford, {Jennifer B} and Xiaoyun Ye and Calafat, {Antonia M} and Braun, {Joseph M} and Russ Hauser",
year = "2017",
month = "8",
day = "18",
doi = "10.1289/EHP1374",
language = "English",
volume = "125",
pages = "087012",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "U.S. Department of Health and Human Services National Institute of Environmental Health Sciences",
number = "8",

}

RIS

TY - JOUR

T1 - Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens

T2 - Results from the Environment And Reproductive Health (EARTH) Study

AU - Nassan, Feiby L

AU - Coull, Brent A

AU - Gaskins, Audrey J

AU - Williams, Michelle A

AU - Skakkebaek, Niels E

AU - Ford, Jennifer B

AU - Ye, Xiaoyun

AU - Calafat, Antonia M

AU - Braun, Joseph M

AU - Hauser, Russ

PY - 2017/8/18

Y1 - 2017/8/18

N2 - BACKGROUND: Personal care products (PCPs) are exposure sources to phthalates and parabens; however, their contribution to men's exposure is understudied.OBJECTIVES: We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men.METHODS: In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a urine sample (2004-2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben. We estimated the covariate-adjusted percent change in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the resulting composite weighted PCP use.RESULTS: Four hundred men contributed 1,037 urine samples (mean of 3/man). The largest percent increase in monoethyl phthalate (MEP) was associated with use of cologne/perfume (83%, p-value<0.01) and deodorant (74%, p-value<0.01). In contrast, the largest percent increase for parabens was associated with the use of suntan/sunblock lotion (66-156%) and hand/body lotion (79-147%). Increases in MEP and parabens were generally greater with PCP use within 6 h of urine collection. A subset of 10 PCPs that were used within 6 h of urine collection contributed to at least 70% of the weighted score and predicted a 254-1,333% increase in MEP and parabens concentrations. Associations between PCP use and concentrations of the other phthalate metabolites were not statistically significant.CONCLUSIONS: We identified 10 PCPs of relevance and demonstrated that their use within 6 h of urine collection strongly predicted MEP and paraben urinary concentrations. https://doi.org/10.1289/EHP1374.

AB - BACKGROUND: Personal care products (PCPs) are exposure sources to phthalates and parabens; however, their contribution to men's exposure is understudied.OBJECTIVES: We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men.METHODS: In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a urine sample (2004-2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben. We estimated the covariate-adjusted percent change in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the resulting composite weighted PCP use.RESULTS: Four hundred men contributed 1,037 urine samples (mean of 3/man). The largest percent increase in monoethyl phthalate (MEP) was associated with use of cologne/perfume (83%, p-value<0.01) and deodorant (74%, p-value<0.01). In contrast, the largest percent increase for parabens was associated with the use of suntan/sunblock lotion (66-156%) and hand/body lotion (79-147%). Increases in MEP and parabens were generally greater with PCP use within 6 h of urine collection. A subset of 10 PCPs that were used within 6 h of urine collection contributed to at least 70% of the weighted score and predicted a 254-1,333% increase in MEP and parabens concentrations. Associations between PCP use and concentrations of the other phthalate metabolites were not statistically significant.CONCLUSIONS: We identified 10 PCPs of relevance and demonstrated that their use within 6 h of urine collection strongly predicted MEP and paraben urinary concentrations. https://doi.org/10.1289/EHP1374.

KW - Adult

KW - Cosmetics

KW - Environmental Exposure

KW - Hazardous Substances

KW - Humans

KW - Male

KW - Parabens

KW - Phthalic Acids

KW - Journal Article

U2 - 10.1289/EHP1374

DO - 10.1289/EHP1374

M3 - Journal article

VL - 125

SP - 087012

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 8

ER -

ID: 52004722