@article{216e70f658034fffa16e918a3fcec862,
title = "Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype",
abstract = "Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence of systemic inflammation is associated with poor clinical outcomes in COPD we assessed patients recruited to the well-characterized ECLIPSE cohort (NCT00292552).",
keywords = "Biological Markers, C-Reactive Protein, Cohort Studies, Cross-Sectional Studies, Fibrinogen, Humans, Interleukin-6, Interleukin-8, Leukocyte Count, Phenotype, Pulmonary Disease, Chronic Obstructive, Questionnaires, Smoking, Spirometry, Systemic Inflammatory Response Syndrome, Tumor Necrosis Factor-alpha",
author = "Alvar Agust{\'i} and Edwards, {Lisa D} and Rennard, {Stephen I} and William MacNee and Ruth Tal-Singer and Miller, {Bruce E} and J{\o}rgen Vestbo and Lomas, {David A} and Calverley, {Peter M A} and Emiel Wouters and Courtney Crim and Yates, {Julie C} and Silverman, {Edwin K} and Coxson, {Harvey O} and Per Bakke and Mayer, {Ruth J} and Bartolome Celli and {Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators}",
year = "2012",
doi = "10.1371/journal.pone.0037483",
language = "English",
volume = "7",
pages = "e37483",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",
}