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Peroxisome proliferator-activated receptor activity correlates with poor survival in patients resected for hepatocellular carcinoma

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@article{2df5512de748409297c4b09442b8aeaa,
title = "Peroxisome proliferator-activated receptor activity correlates with poor survival in patients resected for hepatocellular carcinoma",
abstract = "BACKGROUND/PURPOSE: Few clinically useful biomarkers are known to predict prognosis in patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the correlation between PPAR activity and ALDH7A1 expression and their prognostic significance using RNA sequencing in patients undergoing liver resection for HCC.METHODS: We included patients undergoing liver resection for HCC at a tertiary referral center for hepato-pancreato-biliary surgery between May 2014 and January 2018. PPAR activity and ALDH7A1 expression were evaluated by RNA sequencing and correlated with overall survival, recurrence and histological features.RESULTS: We included 52 patients with a median follow-up of 20.9 months, predominantly males (88.5%) with a single tumor (84.6%) in a non-cirrhotic liver (73.1%). Three-year overall survival was 48.6% in patients with a specific PPAR target gene expression profile (cancer cluster 3) compared with 81.7% in controls (P = .04, Log-rank test). This remained significant (odds ratio 14.02, 95% confidence interval 1.92-102.22, P = .009) when adjusted for age, cirrhosis, microvascular invasion, number of tumors and free resection margins. ALDH7A1 expression was not correlated with PPAR or any outcomes.CONCLUSION: PPAR activity in a subset of tumor samples was associated with reduced overall survival indicating that PPAR may be a valuable prognostic biomarker.",
author = "Hans-Christian Pommergaard and {Preuss Hasselby}, Jane and {Linno Willemoe}, Gro and Adela Ralbovska and {Arendtsen Rostved}, Andreas and Allan Rasmussen and {Aagaard Schultz}, Nicolai and Jens Hillings{\o} and {N{\o}rgaard Larsen}, Peter and Jan-Michael Kugler",
note = "{\textcopyright} 2020 Japanese Society of Hepato-Biliary-Pancreatic Surgery.",
year = "2020",
month = may,
day = "2",
doi = "10.1002/jhbp.745",
language = "English",
journal = "Journal of Hepato-Biliary-Pancreatic Sciences",
issn = "1868-6974",
publisher = "Springer Japan KK",

}

RIS

TY - JOUR

T1 - Peroxisome proliferator-activated receptor activity correlates with poor survival in patients resected for hepatocellular carcinoma

AU - Pommergaard, Hans-Christian

AU - Preuss Hasselby, Jane

AU - Linno Willemoe, Gro

AU - Ralbovska, Adela

AU - Arendtsen Rostved, Andreas

AU - Rasmussen, Allan

AU - Aagaard Schultz, Nicolai

AU - Hillingsø, Jens

AU - Nørgaard Larsen, Peter

AU - Kugler, Jan-Michael

N1 - © 2020 Japanese Society of Hepato-Biliary-Pancreatic Surgery.

PY - 2020/5/2

Y1 - 2020/5/2

N2 - BACKGROUND/PURPOSE: Few clinically useful biomarkers are known to predict prognosis in patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the correlation between PPAR activity and ALDH7A1 expression and their prognostic significance using RNA sequencing in patients undergoing liver resection for HCC.METHODS: We included patients undergoing liver resection for HCC at a tertiary referral center for hepato-pancreato-biliary surgery between May 2014 and January 2018. PPAR activity and ALDH7A1 expression were evaluated by RNA sequencing and correlated with overall survival, recurrence and histological features.RESULTS: We included 52 patients with a median follow-up of 20.9 months, predominantly males (88.5%) with a single tumor (84.6%) in a non-cirrhotic liver (73.1%). Three-year overall survival was 48.6% in patients with a specific PPAR target gene expression profile (cancer cluster 3) compared with 81.7% in controls (P = .04, Log-rank test). This remained significant (odds ratio 14.02, 95% confidence interval 1.92-102.22, P = .009) when adjusted for age, cirrhosis, microvascular invasion, number of tumors and free resection margins. ALDH7A1 expression was not correlated with PPAR or any outcomes.CONCLUSION: PPAR activity in a subset of tumor samples was associated with reduced overall survival indicating that PPAR may be a valuable prognostic biomarker.

AB - BACKGROUND/PURPOSE: Few clinically useful biomarkers are known to predict prognosis in patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the correlation between PPAR activity and ALDH7A1 expression and their prognostic significance using RNA sequencing in patients undergoing liver resection for HCC.METHODS: We included patients undergoing liver resection for HCC at a tertiary referral center for hepato-pancreato-biliary surgery between May 2014 and January 2018. PPAR activity and ALDH7A1 expression were evaluated by RNA sequencing and correlated with overall survival, recurrence and histological features.RESULTS: We included 52 patients with a median follow-up of 20.9 months, predominantly males (88.5%) with a single tumor (84.6%) in a non-cirrhotic liver (73.1%). Three-year overall survival was 48.6% in patients with a specific PPAR target gene expression profile (cancer cluster 3) compared with 81.7% in controls (P = .04, Log-rank test). This remained significant (odds ratio 14.02, 95% confidence interval 1.92-102.22, P = .009) when adjusted for age, cirrhosis, microvascular invasion, number of tumors and free resection margins. ALDH7A1 expression was not correlated with PPAR or any outcomes.CONCLUSION: PPAR activity in a subset of tumor samples was associated with reduced overall survival indicating that PPAR may be a valuable prognostic biomarker.

U2 - 10.1002/jhbp.745

DO - 10.1002/jhbp.745

M3 - Journal article

C2 - 32359017

JO - Journal of Hepato-Biliary-Pancreatic Sciences

JF - Journal of Hepato-Biliary-Pancreatic Sciences

SN - 1868-6974

ER -

ID: 61629453