Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Perivascular neurotransmitters: Regulation of cerebral blood flow and role in primary headaches

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Hybrid PET/MRI imaging in healthy unsedated newborn infants with quantitative rCBF measurements using 15O-water PET

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Effect of hypoxia on BOLD fMRI response and total cerebral blood flow in migraine with aura patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Non-invasive methods for measuring vascular changes in neurovascular headaches

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Cerebral serotonin transporter measurements with [11C]DASB: A review on acquisition and preprocessing across 21 PET centres

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Human brain trauma severity is associated with lectin complement pathway activation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Exploration of physiological and pathophysiological implications of miRNA-143 and miRNA-145 in cerebral arteries

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Exploration of purinergic receptors as potential anti-migraine targets using established pre-clinical migraine models

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Does inflammation have a role in migraine?

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. The changing faces of migraine

    Publikation: Bidrag til tidsskriftLederForskningpeer review

Vis graf over relationer

In order to understand the nature of the relationship between cerebral blood flow (CBF) and primary headaches, we have conducted a literature review with particular emphasis on the role of perivascular neurotransmitters. Primary headaches are in general considered complex polygenic disorders (genetic and environmental influence) with pathophysiological neurovascular alterations. Identified candidate headache genes are associated with neuro- and gliogenesis, vascular development and diseases, and regulation of vascular tone. These findings support a role for the vasculature in primary headache disorders. Moreover, neuronal hyperexcitability and other abnormalities have been observed in primary headaches and related to changes in hemodynamic factors. In particular, this relates to migraine aura and spreading depression. During headache attacks, ganglia such as trigeminal and sphenopalatine (located outside the blood-brain barrier) are variably activated and sensitized which gives rise to vasoactive neurotransmitter release. Sympathetic, parasympathetic and sensory nerves to the cerebral vasculature are activated. During migraine attacks, altered CBF has been observed in brain regions such as the somatosensory cortex, brainstem and thalamus. In regulation of CBF, the individual roles of neurotransmitters are partly known, but much needs to be unraveled with respect to headache disorders.

OriginalsprogEngelsk
TidsskriftJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Vol/bind39
Udgave nummer4
Sider (fra-til)610-632
Antal sider23
ISSN0271-678X
DOI
StatusUdgivet - 2019

ID: 52342152