TY - JOUR
T1 - Peripheral T-cell activation, Th17 cells, regulatory T-cells, and aortic aneurysm in people with HIV
AU - Hove-Skovsgaard, Malene
AU - Høgh, Julie
AU - Pham, Michael Huy Cuong
AU - Knudsen, Andreas Dehlbæk
AU - Gerstoft, Jan
AU - Ostrowski, Sisse Rye
AU - Køber, Lars
AU - Benfield, Thomas
AU - Kofoed, Klaus Fuglsang
AU - Nielsen, Susanne Dam
N1 - Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Here, we investigate if peripheral T-cell activation and proportion of Th17 and T-regulatory cells (Tregs) are associated with aortic aneurysm or aortic diameter in people with HIV. Aorta was examined by computed tomography scans and T-cells by flow cytometry in 428 participants, and aortic aneurysm was found in 32 participants. None of the T-cell subsets were associated with aortic aneurysm, but activated T-cells and Tregs had opposite association to aorta diameter indicating an inverse impact.
AB - Here, we investigate if peripheral T-cell activation and proportion of Th17 and T-regulatory cells (Tregs) are associated with aortic aneurysm or aortic diameter in people with HIV. Aorta was examined by computed tomography scans and T-cells by flow cytometry in 428 participants, and aortic aneurysm was found in 32 participants. None of the T-cell subsets were associated with aortic aneurysm, but activated T-cells and Tregs had opposite association to aorta diameter indicating an inverse impact.
KW - Humans
KW - T-Lymphocytes, Regulatory
KW - HIV Infections/complications
KW - T-Lymphocyte Subsets
KW - Lymphocyte Activation
KW - Aortic Aneurysm/diagnostic imaging
KW - Th17 Cells
UR - http://www.scopus.com/inward/record.url?scp=85166401305&partnerID=8YFLogxK
U2 - 10.1097/QAD.0000000000003612
DO - 10.1097/QAD.0000000000003612
M3 - Letter
C2 - 37534728
SN - 0269-9370
VL - 37
SP - 1765
EP - 1767
JO - AIDS
JF - AIDS
IS - 11
ER -