TY - JOUR
T1 - Peripheral joint and enthesis involvement in patients with newly diagnosed inflammatory bowel disease
T2 - Symptoms, and Clinical and Ultrasound Findings - A Population-Based Cohort Study
AU - Vladimirova, Nora
AU - Terslev, Lene
AU - Attauabi, Mohamed
AU - Madsen, Gorm
AU - Fana, Viktoria
AU - Wiell, Charlotte
AU - Døhn, Uffe Møller
AU - Bendtsen, Flemming
AU - Seidelin, Jakob
AU - Burisch, Johan
AU - Østergaard, Mikkel
N1 - COPECARE
© The Author(s) 2024. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: [email protected].
PY - 2024/7/1
Y1 - 2024/7/1
N2 - OBJECTIVES: Musculoskeletal [MSK] manifestations in patients with inflammatory bowel disease [IBD] are common and associated with poorer outcomes. Hence, early detection is important to optimally tailor treatment. We aimed to determine the prevalence and distribution of inflammatory lesions in peripheral joints and entheses in newly diagnosed IBD patients.DESIGN: Patients with newly diagnosed IBD from a prospective population-based inception cohort were consecutively included. Data on MSK symptoms were collected by questionnaires and by structured rheumatological interview. Peripheral joints and entheses were assessed clinically and by ultrasound [US], using standardized definitions.RESULTS: Of 110 included patients (mean age: 42 years, 40% male, 70 with ulcerative colitis [UC], 40 with Crohn's disease [CD]), a history of ≥1 peripheral musculoskeletal symptom was reported by 49%. Clinical examination revealed peripheral MSK manifestations in 56 [52.3%] patients; 29 [27.1%] had ≥1 tender and/or swollen joints and 49 [45.8%] ≥1 tender entheses. Small peripheral joints were predominantly affected. US found inflammation in ≥1 joint or enthesis in 52 [49.5 %] patients; 29 [27.4 %] had US synovitis in ≥1 joint, while 36 [34%] had US enthesitis. Fibromyalgia classification criteria were fulfilled in seven [7.9%] patients. There was no difference in clinical or US findings between patients with UC and CD, nor between patients with active and inactive IBD.CONCLUSION: Half of the patients with newly diagnosed IBD had inflammation in their peripheral joints and/or entheses, documented by rheumatological clinical and US evaluations. This indicates a need for multidisciplinary collaboration to ensure an optimal therapeutic strategy for suppressing inflammation in all disease domains.
AB - OBJECTIVES: Musculoskeletal [MSK] manifestations in patients with inflammatory bowel disease [IBD] are common and associated with poorer outcomes. Hence, early detection is important to optimally tailor treatment. We aimed to determine the prevalence and distribution of inflammatory lesions in peripheral joints and entheses in newly diagnosed IBD patients.DESIGN: Patients with newly diagnosed IBD from a prospective population-based inception cohort were consecutively included. Data on MSK symptoms were collected by questionnaires and by structured rheumatological interview. Peripheral joints and entheses were assessed clinically and by ultrasound [US], using standardized definitions.RESULTS: Of 110 included patients (mean age: 42 years, 40% male, 70 with ulcerative colitis [UC], 40 with Crohn's disease [CD]), a history of ≥1 peripheral musculoskeletal symptom was reported by 49%. Clinical examination revealed peripheral MSK manifestations in 56 [52.3%] patients; 29 [27.1%] had ≥1 tender and/or swollen joints and 49 [45.8%] ≥1 tender entheses. Small peripheral joints were predominantly affected. US found inflammation in ≥1 joint or enthesis in 52 [49.5 %] patients; 29 [27.4 %] had US synovitis in ≥1 joint, while 36 [34%] had US enthesitis. Fibromyalgia classification criteria were fulfilled in seven [7.9%] patients. There was no difference in clinical or US findings between patients with UC and CD, nor between patients with active and inactive IBD.CONCLUSION: Half of the patients with newly diagnosed IBD had inflammation in their peripheral joints and/or entheses, documented by rheumatological clinical and US evaluations. This indicates a need for multidisciplinary collaboration to ensure an optimal therapeutic strategy for suppressing inflammation in all disease domains.
KW - Adult
KW - Cohort Studies
KW - Colitis, Ulcerative/diagnostic imaging
KW - Crohn Disease/diagnostic imaging
KW - Enthesopathy/diagnostic imaging
KW - Female
KW - Humans
KW - Inflammatory Bowel Diseases/diagnostic imaging
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Prospective Studies
KW - Synovitis/diagnostic imaging
KW - Ultrasonography/methods
UR - http://www.scopus.com/inward/record.url?scp=85200236047&partnerID=8YFLogxK
U2 - 10.1093/ecco-jcc/jjae022
DO - 10.1093/ecco-jcc/jjae022
M3 - Journal article
C2 - 38366120
SN - 1873-9946
VL - 18
SP - 1053
EP - 1070
JO - Journal of Crohn's & colitis
JF - Journal of Crohn's & colitis
IS - 7
ER -