Peripheral bright streaks in tuberous sclerosis

Torgerð Hentze Eliesersdóttir, Elin Holm, Christina Eckmann-Hansen, Marie Wistrup Torm, Mohamed Belmouhand, Michael Larsen

2 Citationer (Scopus)


Purpose: To describe the finding of bright hyperautofluorescent streaks in the peripheral retina in tuberous sclerosis.

Observations: A woman with a pathogenic TSC1 mutation and cutaneous manifestations of tuberous sclerosis underwent fundus examination and was found to have a cluster of thin, yellowish streaks in the inferior peripheral fundus of her left eye. The streaks were hyperautofluorescent in blue light and associated with irregular thickening of the photoreceptor-pigment epithelium complex on optical coherence tomography.

Conclusions and importance: The cluster of outer retinal abnormalities in a sector of the peripheral retina in one eye of a TSC1 patient has features in common with the more centrally located and less numerous lesions called achromatic patches. The resemblance of the streak pattern with the pattern of hypoautofluorescence in X-linked retinopathies suggests that the streaks may represent a clone of cells derived from a single somatic mutation in TSC1. The identification of this lesion type expands the scope of conditions that can be diagnosed by fundus imaging.

TidsskriftAmerican Journal of Ophthalmology Case Reports
Sider (fra-til)101050
StatusUdgivet - jun. 2021


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