Perioperative oxygen fraction - effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial

Christian Sylvest Meyhoff; Jørn Wetterslev; Lars N Jorgensen; Steen W Henneberg; Inger Simonsen; Therese Pulawska; Line R Walker; Nina Skovgaard; Kim Heltø; Peter Gocht-Jensen; Palle Steen Carlsson; Henrik Johannes Rask; Sharaf Karim; Charlotte Green Carlsen; Frank S Jensen; Lars S Rasmussen; PROXI Trial Group

doi:10.1186/1745-6215-9-58

Perioperative oxygen fraction - effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial

Christian Sylvest Meyhoff, Jørn Wetterslev, Lars N Jorgensen, Steen W Henneberg, Inger Simonsen, Therese Pulawska, Line R Walker, Nina Skovgaard, Kim Heltø, Peter Gocht-Jensen, Palle Steen Carlsson, Henrik Johannes Rask, Sharaf Karim, Charlotte Green Carlsen, Frank S Jensen, Lars S Rasmussen, PROXI Trial Group

31 Citationer (Scopus)

Abstrakt

A high perioperative inspiratory oxygen fraction may reduce the risk of surgical site infections, as bacterial eradication by neutrophils depends on wound oxygen tension. Two trials have shown that a high perioperative inspiratory oxygen fraction (FiO(2) = 0.80) significantly reduced risk of surgical site infections after elective colorectal surgery, but a third trial was stopped early because the frequency of surgical site infections was more than doubled in the group receiving FiO(2) = 0.80. It has not been settled if a high inspiratory oxygen fraction increases the risk of pulmonary complications, such as atelectasis, pneumonia and respiratory failure. The aim of our trial is to assess the potential benefits and harms of a high perioperative oxygen fraction in patients undergoing abdominal surgery.

Originalsprog	Engelsk
Tidsskrift	Trials
Vol/bind	9
Sider (fra-til)	58
ISSN	1745-6215
DOI	https://doi.org/10.1186/1745-6215-9-58
Status	Udgivet - 1 jan. 2008

Adgang til dokumentet

10.1186/1745-6215-9-58

Citationsformater

Meyhoff, C. S., Wetterslev, J., Jorgensen, L. N., Henneberg, S. W., Simonsen, I., Pulawska, T., Walker, L. R., Skovgaard, N., Heltø, K., Gocht-Jensen, P., Carlsson, P. S., Rask, H. J., Karim, S., Carlsen, C. G., Jensen, F. S., Rasmussen, L. S., & PROXI Trial Group (2008). Perioperative oxygen fraction - effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial. Trials, 9, 58. https://doi.org/10.1186/1745-6215-9-58

Perioperative oxygen fraction - effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial. / Meyhoff, Christian Sylvest; Wetterslev, Jørn; Jorgensen, Lars N et al.

I: Trials, Bind 9, 01.01.2008, s. 58.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Meyhoff, CS, Wetterslev, J, Jorgensen, LN, Henneberg, SW, Simonsen, I, Pulawska, T, Walker, LR, Skovgaard, N, Heltø, K, Gocht-Jensen, P, Carlsson, PS, Rask, HJ, Karim, S, Carlsen, CG, Jensen, FS, Rasmussen, LS & PROXI Trial Group 2008, 'Perioperative oxygen fraction - effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial', Trials, bind 9, s. 58. https://doi.org/10.1186/1745-6215-9-58

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title = "Perioperative oxygen fraction - effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial",

abstract = "A high perioperative inspiratory oxygen fraction may reduce the risk of surgical site infections, as bacterial eradication by neutrophils depends on wound oxygen tension. Two trials have shown that a high perioperative inspiratory oxygen fraction (FiO(2) = 0.80) significantly reduced risk of surgical site infections after elective colorectal surgery, but a third trial was stopped early because the frequency of surgical site infections was more than doubled in the group receiving FiO(2) = 0.80. It has not been settled if a high inspiratory oxygen fraction increases the risk of pulmonary complications, such as atelectasis, pneumonia and respiratory failure. The aim of our trial is to assess the potential benefits and harms of a high perioperative oxygen fraction in patients undergoing abdominal surgery.",

author = "Meyhoff, {Christian Sylvest} and J{\o}rn Wetterslev and Jorgensen, {Lars N} and Henneberg, {Steen W} and Inger Simonsen and Therese Pulawska and Walker, {Line R} and Nina Skovgaard and Kim Helt{\o} and Peter Gocht-Jensen and Carlsson, {Palle Steen} and Rask, {Henrik Johannes} and Sharaf Karim and Carlsen, {Charlotte Green} and Jensen, {Frank S} and Rasmussen, {Lars S} and {PROXI Trial Group}",

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doi = "10.1186/1745-6215-9-58",

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T1 - Perioperative oxygen fraction - effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial

AU - Meyhoff, Christian Sylvest

AU - Wetterslev, Jørn

AU - Jorgensen, Lars N

AU - Henneberg, Steen W

AU - Simonsen, Inger

AU - Pulawska, Therese

AU - Walker, Line R

AU - Skovgaard, Nina

AU - Heltø, Kim

AU - Gocht-Jensen, Peter

AU - Carlsson, Palle Steen

AU - Rask, Henrik Johannes

AU - Karim, Sharaf

AU - Carlsen, Charlotte Green

AU - Jensen, Frank S

AU - Rasmussen, Lars S

AU - PROXI Trial Group

PY - 2008/1/1

Y1 - 2008/1/1

N2 - A high perioperative inspiratory oxygen fraction may reduce the risk of surgical site infections, as bacterial eradication by neutrophils depends on wound oxygen tension. Two trials have shown that a high perioperative inspiratory oxygen fraction (FiO(2) = 0.80) significantly reduced risk of surgical site infections after elective colorectal surgery, but a third trial was stopped early because the frequency of surgical site infections was more than doubled in the group receiving FiO(2) = 0.80. It has not been settled if a high inspiratory oxygen fraction increases the risk of pulmonary complications, such as atelectasis, pneumonia and respiratory failure. The aim of our trial is to assess the potential benefits and harms of a high perioperative oxygen fraction in patients undergoing abdominal surgery.

AB - A high perioperative inspiratory oxygen fraction may reduce the risk of surgical site infections, as bacterial eradication by neutrophils depends on wound oxygen tension. Two trials have shown that a high perioperative inspiratory oxygen fraction (FiO(2) = 0.80) significantly reduced risk of surgical site infections after elective colorectal surgery, but a third trial was stopped early because the frequency of surgical site infections was more than doubled in the group receiving FiO(2) = 0.80. It has not been settled if a high inspiratory oxygen fraction increases the risk of pulmonary complications, such as atelectasis, pneumonia and respiratory failure. The aim of our trial is to assess the potential benefits and harms of a high perioperative oxygen fraction in patients undergoing abdominal surgery.

U2 - 10.1186/1745-6215-9-58

DO - 10.1186/1745-6215-9-58

M3 - Journal article

C2 - 18945347

VL - 9

SP - 58

JO - Trials

JF - Trials

SN - 1745-6215

ER -

Perioperative oxygen fraction - effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial

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