Perioperative oxygen fraction - effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial

Christian Sylvest Meyhoff, Jørn Wetterslev, Lars N Jorgensen, Steen W Henneberg, Inger Simonsen, Therese Pulawska, Line R Walker, Nina Skovgaard, Kim Heltø, Peter Gocht-Jensen, Palle Steen Carlsson, Henrik Johannes Rask, Sharaf Karim, Charlotte Green Carlsen, Frank S Jensen, Lars S Rasmussen, PROXI Trial Group

32 Citationer (Scopus)

Abstract

A high perioperative inspiratory oxygen fraction may reduce the risk of surgical site infections, as bacterial eradication by neutrophils depends on wound oxygen tension. Two trials have shown that a high perioperative inspiratory oxygen fraction (FiO(2) = 0.80) significantly reduced risk of surgical site infections after elective colorectal surgery, but a third trial was stopped early because the frequency of surgical site infections was more than doubled in the group receiving FiO(2) = 0.80. It has not been settled if a high inspiratory oxygen fraction increases the risk of pulmonary complications, such as atelectasis, pneumonia and respiratory failure. The aim of our trial is to assess the potential benefits and harms of a high perioperative oxygen fraction in patients undergoing abdominal surgery.
OriginalsprogEngelsk
TidsskriftTrials
Vol/bind9
Sider (fra-til)58
ISSN1745-6215
DOI
StatusUdgivet - 1 jan. 2008

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