Periarticular and generalised bone loss in patients with early rheumatoid arthritis: influence of alendronate and intra-articular glucocorticoid treatment. Post hoc analyses from the CIMESTRA trial

T W Jensen, M S Hansen, Kim Hørslev-Petersen, L Hyldstrup, B Abrahamsen, Bente Lomholt Langdahl, Bo Zerahn, Jan Pødenphanth, K Stengaard-Petersen, P Junker, M Ostergaard, Tine Lottenburger, Torkell Juulsgaad Ellingsen, L S Andersen, I Hansen, H Skjødt, J K Pedersen, U B Lauridsen, A J Svendsen, U TarpHanne Lindegaard, Anne Grethe Jurik, Aage Vestergaard, M L Hetland, the Cimestra study group

29 Citationer (Scopus)

Abstract

OBJECTIVES: The aims of this study were to investigate the influence of alendronate and intra-articular betamethasone treatment on bone mineral density (BMD) changes in hand, lumbar spine and femoral neck during 1 year of a treat-to-target study (Cyclosporine, Methotrexate, Steroid in RA (CIMESTRA)). PATIENTS AND METHODS: A hundred and sixty patients with early, active rheumatoid arthritis (RA) received methotrexate, intra-articular betamethasone and ciclosporin /placebo-ciclosporin. Patients with Z-score ≤0 also started alendronate 10 mg/day. BMD of the hand (digital x-ray radiogrammetry (DXR-BMDhand)), BMD of lumbar spine and femoral neck (dual x-ray absorptiometry (DXA-BMDlumbar spine and DXA-BMDfemoral neck)) and x-rays of hands, wrists and forefeet (modified Sharp-van der Heijde score) were measured at baseline and 1 year, with complete data available in 107 patients. RESULTS: The change in BMD in hand, lumbar spine and femoral neck was negatively associated with the dose of intra-articular betamethasone (p
OriginalsprogEngelsk
TidsskriftAnnals of the Rheumatic Diseases
Vol/bind73
Udgave nummer6
Sider (fra-til)1123-1129
Antal sider7
ISSN0003-4967
DOI
StatusUdgivet - 9 maj 2014

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