Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome: A MAGNIMS Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Enterovirus Meningitis in Adults: A Prospective Nationwide Population-Based Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Accuracy of a Deep Learning System for Classification of Papilledema Severity on Ocular Fundus Photographs

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Autoimmune Encephalitis Related to Cancer Treatment With Immune Checkpoint Inhibitors: A Systematic Review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Global Impact of COVID-19 on Stroke Care and IV Thrombolysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Alemtuzumab treatment in Denmark: A national study based on the Danish Multiple Sclerosis Registry

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The levels of the serine protease HTRA1 in cerebrospinal fluid correlate with progression and disability in multiple sclerosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. 2021 MAGNIMS-CMSC-NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  • Massimo Filippi
  • Paolo Preziosa
  • Alessandro Meani
  • Gloria Dalla Costa
  • Sarlota Mesaros
  • Jelena Drulovic
  • Jovana Ivanovic
  • Alex Rovira
  • Mar Tintorè
  • Xavier Montalban
  • Olga Ciccarelli
  • Wallace Brownlee
  • Katherine Miszkiel
  • Christian Enzinger
  • Michael Khalil
  • Frederik Barkhof
  • Eva M M Strijbis
  • Jette L Frederiksen
  • Stig P Cramer
  • Enrico Fainardi
  • Maria Pia Amato
  • Claudio Gasperini
  • Serena Ruggieri
  • Vittorio Martinelli
  • Giancarlo Comi
  • Maria A Rocca
  • MAGNIMS Study Group
Vis graf over relationer

BACKGROUND AND OBJECTIVES: To compare the performance of the 2017 revisions to the McDonald criteria with the 2010 McDonald criteria in establishing multiple sclerosis (MS) diagnosis and predicting prognosis in patients with clinically isolated syndrome (CIS) suggestive of MS.

METHODS: CSF examination and brain and spinal cord MRI obtained ≤5 months from CIS onset and a follow-up brain MRI acquired within 15 months from CIS onset were evaluated in 785 patients with CIS from 9 European centers. Date of second clinical attack and of reaching Expanded Disability Status Scale score (EDSS) ≥3.0, if they occurred, were also collected. Performance of the 2017 and 2010 McDonald criteria for dissemination in space (DIS), dissemination in time (DIT) (including oligoclonal bands assessment), and DIS plus DIT for predicting a second clinical attack (clinically definite MS [CDMS]) and EDSS ≥3.0 at follow-up was evaluated. Time to MS diagnosis for the different criteria was also estimated.

RESULTS: At follow-up (median 69.1 months), 406/785 patients with CIS developed CDMS. At 36 months, the 2017 DIS plus DIT criteria had higher sensitivity (0.83 vs 0.66), lower specificity (0.39 vs 0.60), and similar area under the curve values (0.61 vs 0.63). Median time to MS diagnosis was shorter with the 2017 vs the 2010 or CDMS criteria (2017 revision, 3.2; 2010 revision, 13.0; CDMS, 58.5 months). The 2 sets of criteria similarly predicted EDSS ≥3.0 milestone. Three periventricular lesions improved specificity in patients ≥45 years.

DISCUSSION: The 2017 McDonald criteria showed higher sensitivity, lower specificity, and similar accuracy in predicting CDMS compared to 2010 McDonald criteria, while shortening time to diagnosis of MS.

CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that the 2017 McDonald Criteria more accurately distinguish CDMS in patients early after a CIS when compared to the 2010 McDonald criteria.

OriginalsprogEngelsk
TidsskriftNeurology
Vol/bind98
Udgave nummer1
Sider (fra-til)e1-e14
ISSN0028-3878
DOI
StatusUdgivet - 4 jan. 2022

Bibliografisk note

© 2021 American Academy of Neurology.

ID: 69022054