TY - JOUR
T1 - Performance of 3 rapid tests for discrimination between HIV-1 and HIV-2 in Guinea-Bissau, West Africa
AU - Hønge, Bo Langhoff
AU - Bjarnason Obinah, Magnús Pétur
AU - Jespersen, Sanne
AU - Medina, Candida
AU - Té, David da Silva
AU - da Silva, Zacarias José
AU - Østergaard, Lars
AU - Laursen, Alex Lund
AU - Wejse, Christian
AU - Erikstrup, Christian
AU - Bissau HIV cohort study group
PY - 2014/1/1
Y1 - 2014/1/1
N2 - As HIV-2 is intrinsically resistant to nonnucleoside reverse transcriptase inhibitors, it is mandatory to discriminate between HIV types before initiating antiretroviral treatment. Guinea-Bissau has the world's highest prevalence of HIV-2 and HIV-1/HIV-2 dually infected individuals. We evaluated 3 rapid tests for discrimination between HIV-1, HIV-2, and dual infections among 219 patients from Guinea-Bissau by comparing with the gold standard (INNO-LIA). Genie III HIV-1/HIV-2 was the best performer with regard to discriminatory capacity (agreement 91.8%), followed by Immunoflow HIV1-HIV2 (agreement 90.9%) and SD Bioline HIV-1/2 3.0 (agreement 84.5%). Our results underscore the need for evaluation of tests in relevant populations before implementation.
AB - As HIV-2 is intrinsically resistant to nonnucleoside reverse transcriptase inhibitors, it is mandatory to discriminate between HIV types before initiating antiretroviral treatment. Guinea-Bissau has the world's highest prevalence of HIV-2 and HIV-1/HIV-2 dually infected individuals. We evaluated 3 rapid tests for discrimination between HIV-1, HIV-2, and dual infections among 219 patients from Guinea-Bissau by comparing with the gold standard (INNO-LIA). Genie III HIV-1/HIV-2 was the best performer with regard to discriminatory capacity (agreement 91.8%), followed by Immunoflow HIV1-HIV2 (agreement 90.9%) and SD Bioline HIV-1/2 3.0 (agreement 84.5%). Our results underscore the need for evaluation of tests in relevant populations before implementation.
KW - AIDS Serodiagnosis/methods
KW - Adult
KW - CD4 Lymphocyte Count
KW - Coinfection/diagnosis
KW - Female
KW - Guinea-Bissau/epidemiology
KW - HIV Infections/diagnosis
KW - HIV-1
KW - HIV-2
KW - Humans
KW - Male
KW - Middle Aged
KW - Sensitivity and Specificity
U2 - 10.1097/QAI.0b013e3182a97b81
DO - 10.1097/QAI.0b013e3182a97b81
M3 - Journal article
C2 - 23982658
SN - 1525-4135
VL - 65
SP - 87
EP - 90
JO - Journal of acquired immune deficiency syndromes (1999)
JF - Journal of acquired immune deficiency syndromes (1999)
IS - 1
ER -