TY - JOUR
T1 - Percutaneous vertebroplasty as treatment of malignant vertebral lesions
T2 - a systematic review and GRADE evaluation resulting in a Danish national clinical guideline
AU - Rousing, Rikke
AU - Kirkegaard, Andreas Ole
AU - Nielsen, Michael
AU - Holtved, Eva
AU - Sørensen, Leif Hougaard
AU - Lund, Thomas
AU - Olesen, Viola
AU - Andersen, Mikkel Ø
PY - 2020/7
Y1 - 2020/7
N2 - PURPOSE: To summarize the recommendations from the national clinical guideline published by the Danish Health Authority, regarding cemental augmentation as treatment for painful vertebral lesions, in patients with malignant disease.METHODS: A multidisciplinary working group formulated recommendations based on the GRADE approach.RESULTS: Two of the questions were based on randomized studies and one on professional consensus. The guideline recommends cemental augmentation for painful vertebral lesions in patients with malignant diagnosis, either hematological or non-hematological. Fracture of the posterior wall is not a contradiction to cemental augmentation, but care should always be taken while injecting the cement, to decrease the risk of cemental leaks into the spinal canal.CONCLUSION: The recommendations are based on low-to-moderate quality of evidence or professional consensus as well as patient preferences and positive and harmful effects of the intervention. The working group recommends more randomized studies on patients with different malignant diseases and painful vertebral lesions comparing percutaneous vertebroplasty/kyphoplasty and conservative treatment to confirm the conclusion in this guideline. These slides can be retrieved under Electronic Supplementary Material.
AB - PURPOSE: To summarize the recommendations from the national clinical guideline published by the Danish Health Authority, regarding cemental augmentation as treatment for painful vertebral lesions, in patients with malignant disease.METHODS: A multidisciplinary working group formulated recommendations based on the GRADE approach.RESULTS: Two of the questions were based on randomized studies and one on professional consensus. The guideline recommends cemental augmentation for painful vertebral lesions in patients with malignant diagnosis, either hematological or non-hematological. Fracture of the posterior wall is not a contradiction to cemental augmentation, but care should always be taken while injecting the cement, to decrease the risk of cemental leaks into the spinal canal.CONCLUSION: The recommendations are based on low-to-moderate quality of evidence or professional consensus as well as patient preferences and positive and harmful effects of the intervention. The working group recommends more randomized studies on patients with different malignant diseases and painful vertebral lesions comparing percutaneous vertebroplasty/kyphoplasty and conservative treatment to confirm the conclusion in this guideline. These slides can be retrieved under Electronic Supplementary Material.
U2 - 10.1007/s00586-020-06392-w
DO - 10.1007/s00586-020-06392-w
M3 - Review
C2 - 32246231
SN - 0940-6719
VL - 29
SP - 1573
EP - 1579
JO - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
JF - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
IS - 7
ER -