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Perceived stress and dementia: Results from the Copenhagen city heart study

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Nabe-Nielsen, K, Rod, NH, Hansen, ÅM, Prescott, E, Grynderup, MB, Islamoska, S, Ishtiak-Ahmed, K, Garde, AH, Gyntelberg, F, Mortensen, EL, Phung, TKT, Waldemar, G & Westendorp, RGJ 2020, 'Perceived stress and dementia: Results from the Copenhagen city heart study' Aging & Mental Health, s. epub brit 100120. https://doi.org/10.1080/13607863.2019.1625304

APA

Nabe-Nielsen, K., Rod, N. H., Hansen, Å. M., Prescott, E., Grynderup, M. B., Islamoska, S., ... Westendorp, R. G. J. (Accepteret/In press). Perceived stress and dementia: Results from the Copenhagen city heart study. Aging & Mental Health, epub brit 100120. https://doi.org/10.1080/13607863.2019.1625304

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MLA

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Author

Nabe-Nielsen, Kirsten ; Rod, Naja Hulvej ; Hansen, Åse Marie ; Prescott, Eva ; Grynderup, Matias Brødsgaard ; Islamoska, Sabrina ; Ishtiak-Ahmed, Kazi ; Garde, Anne Helene ; Gyntelberg, Finn ; Mortensen, Erik Lykke ; Phung, Thien Kieu Thi ; Waldemar, Gunhild ; Westendorp, Rudi G J. / Perceived stress and dementia : Results from the Copenhagen city heart study. I: Aging & Mental Health. 2020 ; s. epub brit 100120.

Bibtex

@article{03338444e92c43d19ef5f0b78cda7442,
title = "Perceived stress and dementia: Results from the Copenhagen city heart study",
abstract = "Objectives: We investigated if perceived stress in midlife increased the risk of dementia. Furthermore, we explored differences between subgroups related to sex, age and employment status when reporting stress. Methods: In this longitudinal study, we used information on perceived stress from 10,814 participants (mean age 56.7 years). Participants were followed through Danish national registers for development of dementia. Participants were considered at risk of dementia from the date they turned 60 years. Perceived stress was assessed as a combination of self-reported intensity and frequency of stress, and categorized into low (score 0-1), medium (score 2-4), and high stress (score 5-6). We used Poisson regression to estimate incidence rate ratios (IRR) and their 95{\%} confidence intervals (CI) and adjusted for sociodemographic factors and psychiatric morbidity at baseline (main model) as well as cardio/cerebrovascular diseases and health behaviors at baseline (additional model). Results: The mean follow-up time was 13.8 years, and 1,519 participants were registered with dementia. Dementia risk was higher in participants reporting medium stress (IRR = 1.11, 95{\%} CI: 0.99-1.24) and high stress (IRR = 1.36, 95{\%} CI: 1.13-1.65). Adjustment for cardio/cerebrovascular diseases and health behaviors did not alter the results. We did not find strong support for differences between subgroups, although the association between stress and dementia was stronger for those who were employed at the time of reporting high stress. Conclusion: Our results provide empirical support for an effect of perceived stress on the risk of dementia in old age.",
author = "Kirsten Nabe-Nielsen and Rod, {Naja Hulvej} and Hansen, {{\AA}se Marie} and Eva Prescott and Grynderup, {Matias Br{\o}dsgaard} and Sabrina Islamoska and Kazi Ishtiak-Ahmed and Garde, {Anne Helene} and Finn Gyntelberg and Mortensen, {Erik Lykke} and Phung, {Thien Kieu Thi} and Gunhild Waldemar and Westendorp, {Rudi G J}",
year = "2020",
doi = "10.1080/13607863.2019.1625304",
language = "English",
pages = "epub brit 100120",
journal = "Aging and Mental Health",
issn = "1360-7863",
publisher = "Routledge",

}

RIS

TY - JOUR

T1 - Perceived stress and dementia

T2 - Results from the Copenhagen city heart study

AU - Nabe-Nielsen, Kirsten

AU - Rod, Naja Hulvej

AU - Hansen, Åse Marie

AU - Prescott, Eva

AU - Grynderup, Matias Brødsgaard

AU - Islamoska, Sabrina

AU - Ishtiak-Ahmed, Kazi

AU - Garde, Anne Helene

AU - Gyntelberg, Finn

AU - Mortensen, Erik Lykke

AU - Phung, Thien Kieu Thi

AU - Waldemar, Gunhild

AU - Westendorp, Rudi G J

PY - 2020

Y1 - 2020

N2 - Objectives: We investigated if perceived stress in midlife increased the risk of dementia. Furthermore, we explored differences between subgroups related to sex, age and employment status when reporting stress. Methods: In this longitudinal study, we used information on perceived stress from 10,814 participants (mean age 56.7 years). Participants were followed through Danish national registers for development of dementia. Participants were considered at risk of dementia from the date they turned 60 years. Perceived stress was assessed as a combination of self-reported intensity and frequency of stress, and categorized into low (score 0-1), medium (score 2-4), and high stress (score 5-6). We used Poisson regression to estimate incidence rate ratios (IRR) and their 95% confidence intervals (CI) and adjusted for sociodemographic factors and psychiatric morbidity at baseline (main model) as well as cardio/cerebrovascular diseases and health behaviors at baseline (additional model). Results: The mean follow-up time was 13.8 years, and 1,519 participants were registered with dementia. Dementia risk was higher in participants reporting medium stress (IRR = 1.11, 95% CI: 0.99-1.24) and high stress (IRR = 1.36, 95% CI: 1.13-1.65). Adjustment for cardio/cerebrovascular diseases and health behaviors did not alter the results. We did not find strong support for differences between subgroups, although the association between stress and dementia was stronger for those who were employed at the time of reporting high stress. Conclusion: Our results provide empirical support for an effect of perceived stress on the risk of dementia in old age.

AB - Objectives: We investigated if perceived stress in midlife increased the risk of dementia. Furthermore, we explored differences between subgroups related to sex, age and employment status when reporting stress. Methods: In this longitudinal study, we used information on perceived stress from 10,814 participants (mean age 56.7 years). Participants were followed through Danish national registers for development of dementia. Participants were considered at risk of dementia from the date they turned 60 years. Perceived stress was assessed as a combination of self-reported intensity and frequency of stress, and categorized into low (score 0-1), medium (score 2-4), and high stress (score 5-6). We used Poisson regression to estimate incidence rate ratios (IRR) and their 95% confidence intervals (CI) and adjusted for sociodemographic factors and psychiatric morbidity at baseline (main model) as well as cardio/cerebrovascular diseases and health behaviors at baseline (additional model). Results: The mean follow-up time was 13.8 years, and 1,519 participants were registered with dementia. Dementia risk was higher in participants reporting medium stress (IRR = 1.11, 95% CI: 0.99-1.24) and high stress (IRR = 1.36, 95% CI: 1.13-1.65). Adjustment for cardio/cerebrovascular diseases and health behaviors did not alter the results. We did not find strong support for differences between subgroups, although the association between stress and dementia was stronger for those who were employed at the time of reporting high stress. Conclusion: Our results provide empirical support for an effect of perceived stress on the risk of dementia in old age.

U2 - 10.1080/13607863.2019.1625304

DO - 10.1080/13607863.2019.1625304

M3 - Journal article

SP - epub brit 100120

JO - Aging and Mental Health

JF - Aging and Mental Health

SN - 1360-7863

ER -

ID: 58020335