TY - JOUR
T1 - Peptide-containing nerve fibres in human extracranial tissue
T2 - a morphological basis for neuropeptide involvement in extracranial pain?
AU - Uddman, Rolf
AU - Edvinsson, Lars
AU - Jansen, Inger
AU - Stiernholm, Pia
AU - Jensen, Kai
AU - Olesen, Jes
AU - Sundler, Frank
PY - 1986/12
Y1 - 1986/12
N2 - It has been suggested that a number of peptides may be involved in the transmission of pain. In order to evaluate the possible role of peptides in the development of headache, we have, in the present study, examined the presence of nerve fibres containing neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP) in human temporal and occipital tissues. In the skin, delicate VIP, SP and CGRP fibres occur beneath the epidermis, sometimes running into the folds of the dermal ridges. In deeper layers of the dermis, small blood vessels are occasionally surrounded by single nerve fibres containing NPY, VIP, SP and CGRP. Large temporal and occipital arteries are surrounded by a meshwork of such fibres. In addition, NPY and VIP fibres are seen around sweat glands and hair follicles. Smooth muscle bundles in the dermis are surrounded by VIP fibres, whereas the temporal muscle per se is devoid of such fibres.
AB - It has been suggested that a number of peptides may be involved in the transmission of pain. In order to evaluate the possible role of peptides in the development of headache, we have, in the present study, examined the presence of nerve fibres containing neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP) in human temporal and occipital tissues. In the skin, delicate VIP, SP and CGRP fibres occur beneath the epidermis, sometimes running into the folds of the dermal ridges. In deeper layers of the dermis, small blood vessels are occasionally surrounded by single nerve fibres containing NPY, VIP, SP and CGRP. Large temporal and occipital arteries are surrounded by a meshwork of such fibres. In addition, NPY and VIP fibres are seen around sweat glands and hair follicles. Smooth muscle bundles in the dermis are surrounded by VIP fibres, whereas the temporal muscle per se is devoid of such fibres.
KW - Calcitonin Gene-Related Peptide
KW - Fluorescent Antibody Technique
KW - Headache/physiopathology
KW - Histocytochemistry
KW - Humans
KW - Muscles/innervation
KW - Nerve Fibers/analysis
KW - Neuropeptide Y/analysis
KW - Neuropeptides/analysis
KW - Skin/innervation
KW - Substance P/analysis
KW - Sweat Glands/innervation
KW - Temporal Arteries/innervation
KW - Temporal Muscle/innervation
KW - Vasoactive Intestinal Peptide/analysis
U2 - 10.1016/0304-3959(86)90162-4
DO - 10.1016/0304-3959(86)90162-4
M3 - Journal article
C2 - 2433670
SN - 0304-3959
VL - 27
SP - 391
EP - 399
JO - Pain
JF - Pain
IS - 3
ER -