Penetrance of hypertrophic cardiomyopathy in children and adolescents: a 12-year follow-up study of clinical screening and predictive genetic testing

Morten K Jensen; Ole Havndrup; Michael Christiansen; Paal S Andersen; Birgitte Diness; Anna Axelsson; Flemming Skovby; Lars Køber; Henning Bundgaard

doi:10.1161/CIRCULATIONAHA.111.090514

Penetrance of hypertrophic cardiomyopathy in children and adolescents: a 12-year follow-up study of clinical screening and predictive genetic testing

Morten K Jensen
, Ole Havndrup
, Michael Christiansen
, Paal S Andersen
, Birgitte Diness
, Anna Axelsson
, Flemming Skovby
, Lars Køber
, Henning Bundgaard

Afdeling for Genetik

120 Citationer (Scopus)

Abstract

The penetrance of hypertrophic cardiomyopathy (HCM) during childhood and adolescence has been only sparsely described. We studied the penetrance of HCM and the short- and long-term outcomes of clinical screening and predictive genetic testing of child relatives of patients with HCM.

Originalsprog	Engelsk
Tidsskrift	Circulation (Baltimore)
Vol/bind	127
Udgave nummer	1
Sider (fra-til)	48-54
Antal sider	7
ISSN	0009-7322
DOI	https://doi.org/10.1161/CIRCULATIONAHA.111.090514
Status	Udgivet - 1 jan. 2013

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10.1161/CIRCULATIONAHA.111.090514

Citationsformater

Jensen, M. K., Havndrup, O., Christiansen, M., Andersen, P. S., Diness, B., Axelsson, A., Skovby, F., Køber, L., & Bundgaard, H. (2013). Penetrance of hypertrophic cardiomyopathy in children and adolescents: a 12-year follow-up study of clinical screening and predictive genetic testing. Circulation (Baltimore), 127(1), 48-54. https://doi.org/10.1161/CIRCULATIONAHA.111.090514

Jensen, MK, Havndrup, O, Christiansen, M, Andersen, PS, Diness, B , Axelsson, A, Skovby, F, Køber, L & Bundgaard, H 2013, 'Penetrance of hypertrophic cardiomyopathy in children and adolescents: a 12-year follow-up study of clinical screening and predictive genetic testing', Circulation (Baltimore), bind 127, nr. 1, s. 48-54. https://doi.org/10.1161/CIRCULATIONAHA.111.090514

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abstract = "The penetrance of hypertrophic cardiomyopathy (HCM) during childhood and adolescence has been only sparsely described. We studied the penetrance of HCM and the short- and long-term outcomes of clinical screening and predictive genetic testing of child relatives of patients with HCM.",

keywords = "Adolescent, Adult, Age of Onset, Cardiomyopathy, Hypertrophic, Familial, Child, Echocardiography, Electrocardiography, Family, Follow-Up Studies, Genetic Predisposition to Disease, Genetic Testing, Heterozygote, Humans, Penetrance, Phenotype, Predictive Value of Tests, Risk Factors, Sarcomeres",

author = "Jensen, \{Morten K\} and Ole Havndrup and Michael Christiansen and Andersen, \{Paal S\} and Birgitte Diness and Anna Axelsson and Flemming Skovby and Lars K{\o}ber and Henning Bundgaard",

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doi = "10.1161/CIRCULATIONAHA.111.090514",

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T2 - a 12-year follow-up study of clinical screening and predictive genetic testing

AU - Jensen, Morten K

AU - Havndrup, Ole

AU - Christiansen, Michael

AU - Andersen, Paal S

AU - Diness, Birgitte

AU - Axelsson, Anna

AU - Skovby, Flemming

AU - Køber, Lars

AU - Bundgaard, Henning

PY - 2013/1/1

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N2 - The penetrance of hypertrophic cardiomyopathy (HCM) during childhood and adolescence has been only sparsely described. We studied the penetrance of HCM and the short- and long-term outcomes of clinical screening and predictive genetic testing of child relatives of patients with HCM.

AB - The penetrance of hypertrophic cardiomyopathy (HCM) during childhood and adolescence has been only sparsely described. We studied the penetrance of HCM and the short- and long-term outcomes of clinical screening and predictive genetic testing of child relatives of patients with HCM.

KW - Adolescent

KW - Adult

KW - Age of Onset

KW - Cardiomyopathy, Hypertrophic, Familial

KW - Child

KW - Echocardiography

KW - Electrocardiography

KW - Family

KW - Follow-Up Studies

KW - Genetic Predisposition to Disease

KW - Genetic Testing

KW - Heterozygote

KW - Humans

KW - Penetrance

KW - Phenotype

KW - Predictive Value of Tests

KW - Risk Factors

KW - Sarcomeres

U2 - 10.1161/CIRCULATIONAHA.111.090514

DO - 10.1161/CIRCULATIONAHA.111.090514

M3 - Journal article

C2 - 23197161

SN - 0009-7322

VL - 127

SP - 48

EP - 54

JO - Circulation (Baltimore)

JF - Circulation (Baltimore)

IS - 1

ER -

Penetrance of hypertrophic cardiomyopathy in children and adolescents: a 12-year follow-up study of clinical screening and predictive genetic testing

Abstract

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