TY - JOUR
T1 - Pattern of distribution of T lymphocytes, Langerhans cells and HLA-DR bearing cells in normal human oral mucosa
AU - Reibel, J
AU - Dabelsteen, E
AU - Kenrad, B
AU - Buschard, K
PY - 1985/12
Y1 - 1985/12
N2 - The tissue distribution of helper/inducer and suppressor/cytotoxic T cells, Langerhans cells (LC) and HLA-DR bearing cells was determined in normal oral mucosa by use of monoclonal antibodies OKT4, OKT8, OKT6 and OKIa1, respectively. OKT4+ and OKT8+ cells were invariably present in normal oral epithelium and in the lamina propria. OKT8+ cells were consistently seen inside the basal cell layer of the epithelium. The distribution of LC in oral epithelium showed regional variation. In palatal epithelium LC were evenly distributed in the basal half of the epithelium, whereas in buccal mucosa the highest concentration of LC was seen in the epithelium overlying the tips of connective tissue papillae. OKIa1 stained dendritic cells in the epithelium and plump cells with small dendritic processes in the connective tissue. Some of the latter were located close to the basal cells of the epithelium. The consistent relationship between immunocompetent cells and the epithelium of the oral mucosa suggests the presence of a local immunologic defence barrier in the oral mucosa.
AB - The tissue distribution of helper/inducer and suppressor/cytotoxic T cells, Langerhans cells (LC) and HLA-DR bearing cells was determined in normal oral mucosa by use of monoclonal antibodies OKT4, OKT8, OKT6 and OKIa1, respectively. OKT4+ and OKT8+ cells were invariably present in normal oral epithelium and in the lamina propria. OKT8+ cells were consistently seen inside the basal cell layer of the epithelium. The distribution of LC in oral epithelium showed regional variation. In palatal epithelium LC were evenly distributed in the basal half of the epithelium, whereas in buccal mucosa the highest concentration of LC was seen in the epithelium overlying the tips of connective tissue papillae. OKIa1 stained dendritic cells in the epithelium and plump cells with small dendritic processes in the connective tissue. Some of the latter were located close to the basal cells of the epithelium. The consistent relationship between immunocompetent cells and the epithelium of the oral mucosa suggests the presence of a local immunologic defence barrier in the oral mucosa.
KW - Adolescent
KW - Adult
KW - Antibodies, Monoclonal
KW - Cell Count
KW - HLA-DR Antigens
KW - Histocompatibility Antigens Class II/analysis
KW - Humans
KW - Langerhans Cells/cytology
KW - Mouth Mucosa/cytology
KW - T-Lymphocytes/classification
KW - T-Lymphocytes, Cytotoxic/cytology
KW - T-Lymphocytes, Helper-Inducer/cytology
KW - T-Lymphocytes, Regulatory/cytology
U2 - 10.1111/j.1600-0722.1985.tb01349.x
DO - 10.1111/j.1600-0722.1985.tb01349.x
M3 - Journal article
C2 - 2937133
SN - 0029-845X
VL - 93
SP - 513
EP - 521
JO - Scandinavian journal of dental research
JF - Scandinavian journal of dental research
IS - 6
ER -