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Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise

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@article{02a6c277d47a4eda89d72623ed2eaa2c,
title = "Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise",
abstract = "Introduction: Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in APOE ε4 carriers.Methods: In this post hoc subgroup analysis study, we investigated whether the beneficial effect of an exercise intervention in patients with mild AD was dependent on the patients' APOE genotype.Results: We found that patients who were APOE ε4 carriers benefitted more from the exercise intervention by preservation of cognitive performance and improvement in physical measures.Discussion: This exploratory study establishes a possible connection between the beneficial effects of exercise in AD and the patients' APOE genotype. These findings, if validated, could greatly impact the clinical management of patients with AD and those at risk for developing AD.",
author = "Jensen, {Camilla Steen} and Simonsen, {Anja Hviid} and Volkert Siersma and Nina Beyer and Frederiksen, {Kristian Steen} and Hanne Gottrup and Kristine Hoffman and Peter H{\o}gh and Ruth Frikke-Schmidt and Sobol, {Nanna Aue} and Gunhild Waldemar and Lene Wermuth and Hasselbalch, {Steen Gregers}",
year = "2019",
month = "1",
doi = "10.1016/j.trci.2019.02.007",
language = "English",
volume = "5",
pages = "99--106",
journal = "Alzheimer's & Dementia: Translational Research & Clinical Interventions",
issn = "2352-8737",
publisher = "Elsevier Inc",

}

RIS

TY - JOUR

T1 - Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise

AU - Jensen, Camilla Steen

AU - Simonsen, Anja Hviid

AU - Siersma, Volkert

AU - Beyer, Nina

AU - Frederiksen, Kristian Steen

AU - Gottrup, Hanne

AU - Hoffman, Kristine

AU - Høgh, Peter

AU - Frikke-Schmidt, Ruth

AU - Sobol, Nanna Aue

AU - Waldemar, Gunhild

AU - Wermuth, Lene

AU - Hasselbalch, Steen Gregers

PY - 2019/1

Y1 - 2019/1

N2 - Introduction: Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in APOE ε4 carriers.Methods: In this post hoc subgroup analysis study, we investigated whether the beneficial effect of an exercise intervention in patients with mild AD was dependent on the patients' APOE genotype.Results: We found that patients who were APOE ε4 carriers benefitted more from the exercise intervention by preservation of cognitive performance and improvement in physical measures.Discussion: This exploratory study establishes a possible connection between the beneficial effects of exercise in AD and the patients' APOE genotype. These findings, if validated, could greatly impact the clinical management of patients with AD and those at risk for developing AD.

AB - Introduction: Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in APOE ε4 carriers.Methods: In this post hoc subgroup analysis study, we investigated whether the beneficial effect of an exercise intervention in patients with mild AD was dependent on the patients' APOE genotype.Results: We found that patients who were APOE ε4 carriers benefitted more from the exercise intervention by preservation of cognitive performance and improvement in physical measures.Discussion: This exploratory study establishes a possible connection between the beneficial effects of exercise in AD and the patients' APOE genotype. These findings, if validated, could greatly impact the clinical management of patients with AD and those at risk for developing AD.

U2 - 10.1016/j.trci.2019.02.007

DO - 10.1016/j.trci.2019.02.007

M3 - Journal article

VL - 5

SP - 99

EP - 106

JO - Alzheimer's & Dementia: Translational Research & Clinical Interventions

JF - Alzheimer's & Dementia: Translational Research & Clinical Interventions

SN - 2352-8737

ER -

ID: 58019954