TY - JOUR
T1 - Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise
AU - Jensen, Camilla Steen
AU - Simonsen, Anja Hviid
AU - Siersma, Volkert
AU - Beyer, Nina
AU - Frederiksen, Kristian Steen
AU - Gottrup, Hanne
AU - Hoffman, Kristine
AU - Høgh, Peter
AU - Frikke-Schmidt, Ruth
AU - Sobol, Nanna Aue
AU - Waldemar, Gunhild
AU - Wermuth, Lene
AU - Hasselbalch, Steen Gregers
PY - 2019/1
Y1 - 2019/1
N2 - Introduction: Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in APOE ε4 carriers.Methods: In this post hoc subgroup analysis study, we investigated whether the beneficial effect of an exercise intervention in patients with mild AD was dependent on the patients' APOE genotype.Results: We found that patients who were APOE ε4 carriers benefitted more from the exercise intervention by preservation of cognitive performance and improvement in physical measures.Discussion: This exploratory study establishes a possible connection between the beneficial effects of exercise in AD and the patients' APOE genotype. These findings, if validated, could greatly impact the clinical management of patients with AD and those at risk for developing AD.
AB - Introduction: Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in APOE ε4 carriers.Methods: In this post hoc subgroup analysis study, we investigated whether the beneficial effect of an exercise intervention in patients with mild AD was dependent on the patients' APOE genotype.Results: We found that patients who were APOE ε4 carriers benefitted more from the exercise intervention by preservation of cognitive performance and improvement in physical measures.Discussion: This exploratory study establishes a possible connection between the beneficial effects of exercise in AD and the patients' APOE genotype. These findings, if validated, could greatly impact the clinical management of patients with AD and those at risk for developing AD.
KW - Alzheimer's disease
KW - APOE
KW - Exercise
KW - Genetic
KW - Intervention
UR - http://www.scopus.com/inward/record.url?scp=85063894609&partnerID=8YFLogxK
U2 - 10.1016/j.trci.2019.02.007
DO - 10.1016/j.trci.2019.02.007
M3 - Journal article
C2 - 31011620
SN - 2352-8737
VL - 5
SP - 99
EP - 106
JO - Alzheimer's & Dementia: Translational Research & Clinical Interventions
JF - Alzheimer's & Dementia: Translational Research & Clinical Interventions
ER -