Pathways driving tendinopathy and enthesitis: siblings or distant cousins in musculoskeletal medicine?

Lindsay A N Crowe, Moeed Akbar, Robert-Jan de Vos, Paul D Kirwan, Michael Kjaer, Carles Pedret, Iain B McInnes, Stefan Siebert, Neal L Millar

2 Citationer (Scopus)

Abstract

Tendinopathy and enthesitis share clinical, anatomical, and molecular parallels. However, their relationship is complex, presenting challenges in diagnosis and treatment. The biomechanics underlying these pathologies, together with relative immune and stromal contributions to pathology, are characterised by crucial comparative elements. However, methodologies used to study enthesitis and tendinopathy have been divergent, which could account for discrepancies in how these conditions are perceived and treated. In this Review, we summarise key clinical parallels between these two common presentations in musculoskeletal medicine and address factors that currently preclude development of more effective therapeutics. Furthermore, we describe molecular similarities and disparities that govern pathological mechanisms in tendinopathy and enthesitis, thus informing translational studies and treatment strategies.

OriginalsprogEngelsk
TidsskriftThe Lancet Rheumatology
Vol/bind5
Udgave nummer5
Sider (fra-til)e293-e304
ISSN2665-9913
DOI
StatusUdgivet - maj 2023

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