Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Pathophysiology and management of diabetic gastroenteropathy

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Meta-analysis of individual patient data of albumin dialysis in acute-on-chronic liver failure: focus on treatment intensity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Teduglutide, a novel glucagon-like peptide 2 analog, in the treatment of patients with short bowel syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Possible interactions between dietary fibres and 5-aminosalicyclic acid

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Diabetic Neuropathy influences the peripheral and central nervous integration of the nociceptive withdrawal reflex

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  2. Thalamic atrophy is associated to intra-thalamic metabolites in type 1 diabetes with severe distal symmetrical polyneuropathy

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  • Theresa Meldgaard
  • Jutta Keller
  • Anne Estrup Olesen
  • Søren Schou Olesen
  • Klaus Krogh
  • Mette Borre
  • Adam Farmer
  • Birgitte Brock
  • Christina Brock
  • Asbjørn Mohr Drewes
Vis graf over relationer

Polyneuropathy is a common complication to diabetes. Neuropathies within the enteric nervous system are associated with gastroenteropathy and marked symptoms that severely reduce quality of life. Symptoms are pleomorphic but include nausea, vomiting, dysphagia, dyspepsia, pain, bloating, diarrhoea, constipation and faecal incontinence. The aims of this review are fourfold. First, to provide a summary of the pathophysiology underlying diabetic gastroenteropathy. Secondly to give an overview of the diagnostic methods. Thirdly, to provide clinicians with a focussed overview of current and future methods for pharmacological and nonpharmacological treatment modalities. Pharmacological management is categorised according to symptoms arising from the upper or lower gut as well as sensory dysfunctions. Dietary management is central to improvement of symptoms and is discussed in detail, and neuromodulatory treatment modalities and other emerging management strategies for diabetic gastroenteropathy are discussed. Finally, we propose a diagnostic/investigation algorithm that can be used to support multidisciplinary management.

OriginalsprogEngelsk
TidsskriftTherapeutic Advances in Gastroenterology
Vol/bind12
Sider (fra-til)1-17
Antal sider17
ISSN1756-283X
DOI
StatusUdgivet - 17 jun. 2019

ID: 57539606