Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Pathophysiological-based treatments of complications of cirrhosis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. True Chromogranin A concentrations in plasma from patients with small intestinal neuroendocrine tumours

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Plasma calprotectin is superior to serum calprotectin as a biomarker of intestinal inflammation in ulcerative Colitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Gastric cancer and gastrin: on the interaction of Helicobacter pylori gastritis and acid inhibitory induced hypergastrinemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The clinical course of common bile duct stone clearance with endoscopic retrograde cholangio-pancreaticography

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Fibrogenesis and inflammation contribute to the pathogenesis of cirrhotic cardiomyopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cardiodynamic state is associated with systemic inflammation and fatal acute-on-chronic liver failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Episodic and Chronic Cluster Headache: Differences in Family History, Traumatic Head Injury, and Chronorisk

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Mechanisms in fluid retention - Towards a mutual concept

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

Detailed knowledge and understanding of the pathophysiological mechanisms and changes in hepatic and splanchnic function leading to the development of haemodynamic changes and portal hypertension in patients with cirrhosis are essential since it guides the search for targets to ameliorate liver-related abnormalities. Recent research has focused on the gut-liver axis, changes in intestinal permeability, translocation of bacterial products, and inflammation as important drivers of haemodynamic alterations and thereby targets for treatment. Additionally, treatment strategies should focus on microbiotic modulation, antiangiogenics, anti-inflammatory strategies, and modulation of bile acid metabolism. This paper aims to review contemporary pathophysiological-based treatment principles of the major complications of cirrhosis and portal hypertension and future targets for treatment.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Gastroenterology
Vol/bind55
Udgave nummer4
Sider (fra-til)383-394
Antal sider12
ISSN0036-5521
DOI
StatusUdgivet - apr. 2020

ID: 59656383