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Region Hovedstaden - en del af Københavns Universitetshospital
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Pathophysiological-based treatments of complications of cirrhosis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Vis graf over relationer

Detailed knowledge and understanding of the pathophysiological mechanisms and changes in hepatic and splanchnic function leading to the development of haemodynamic changes and portal hypertension in patients with cirrhosis are essential since it guides the search for targets to ameliorate liver-related abnormalities. Recent research has focused on the gut-liver axis, changes in intestinal permeability, translocation of bacterial products, and inflammation as important drivers of haemodynamic alterations and thereby targets for treatment. Additionally, treatment strategies should focus on microbiotic modulation, antiangiogenics, anti-inflammatory strategies, and modulation of bile acid metabolism. This paper aims to review contemporary pathophysiological-based treatment principles of the major complications of cirrhosis and portal hypertension and future targets for treatment.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Gastroenterology
Vol/bind55
Udgave nummer4
Sider (fra-til)383-394
Antal sider12
ISSN0036-5521
DOI
StatusUdgivet - apr. 2020

ID: 59656383