Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Pathophysiological Mechanisms in Migraine and the Identification of New Therapeutic Targets

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Targeting BKCa Channels in Migraine: Rationale and Perspectives

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Anti-CD20 Monoclonal Antibodies for Relapsing and Progressive Multiple Sclerosis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Assessment of Opicinumab in Acute Optic Neuritis Using Multifocal Visual Evoked Potential

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The Safety of Second-Generation Antipsychotics During Pregnancy: A Clinically Focused Review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Oral rimegepant for migraine prevention

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  2. Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Migraine is a strongly disabling disease characterized by a unilateral throbbing headache lasting for up to 72 h for each individual attack. There have been many theories on the pathophysiology of migraine throughout the years. Currently, the neurovascular theory dominates, suggesting clear involvement of the trigeminovascular system. The most recent data show that a migraine attack most likely originates in the hypothalamus and activates the trigeminal nucleus caudalis (TNC). Although the mechanisms are unknown, activation of the TNC leads to peripheral release of calcitonin gene-related protein (CGRP), most likely from C-fibers. During the past year monoclonal antibodies against CGRP or the CGRP receptor have emerged as the most promising targets for migraine therapy, and at the same time established the strong involvement of CGRP in the pathophysiology of migraine. The viewpoint presented here focuses further on the activation of the CGRP receptor on the sensory Aδ-fiber, leading to the sensation of pain. The CGRP receptor activates adenylate cyclase, which leads to an increase in cyclic adenosine monophosphate (cAMP). We hypothesize that cAMP activates the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, triggering an action potential sensed as pain. The mechanisms behind migraine pain on a molecular level, particularly their importance to cAMP, provide clues to potential new anti-migraine targets. In this article we focus on the development of targets related to the CGRP system, and further include novel targets such as the pituitary adenylate cyclase-activating peptide (PACAP) system, the serotonin 5-HT1F receptor, purinergic receptors, HCN channels, adenosine triphosphate-sensitive potassium channels (KATP), and the glutaminergic system.

OriginalsprogEngelsk
TidsskriftCNS Drugs
Vol/bind33
Udgave nummer6
Sider (fra-til)525-537
Antal sider13
ISSN1172-7047
DOI
StatusUdgivet - 2019

ID: 57158518