Pathological and therapeutic possibilities in inhibiting ocular angionesis

Yousif Subhi; Lasse Jørgensen Cehofski; Anders Højslet Vestergaard; Torben Lykke Sørensen; Jakob Grauslund

Pathological and therapeutic possibilities in inhibiting ocular angionesis

Yousif Subhi, Lasse Jørgensen Cehofski, Anders Højslet Vestergaard, Torben Lykke Sørensen, Jakob Grauslund

Abstract

In a variety of corneal and retinal diseases, ocular ischaemia mediates vascular endothelial growth factor (VEGF) expression, which in turn causes angiogenesis and increased vascular permeability. Consequently, VEGF-inhibitory treatment has been introduced in different ocular diseases. Hypoxia-inducible factor (HIF)-1α is an upstream regulator of VEGF-A, and increased HIF-1α expression has been established in ocular animal models. Upcoming translational studies are expected to increase our understanding of the complex balance between pro- and anti-angiogenic factors in the eye.

Bidragets oversatte titel	Pathological and therapeutic possibilities in inhibiting ocular angionesis
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	182
Udgave nummer	44
ISSN	0041-5782
Status	Udgivet - 26 okt. 2020
Udgivet eksternt	Ja

Emneord

Angiogenesis Inducing Agents
Animals
Vascular Endothelial Growth Factor A

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Citationsformater

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title = "Pathological and therapeutic possibilities in inhibiting ocular angionesis",

abstract = "In a variety of corneal and retinal diseases, ocular ischaemia mediates vascular endothelial growth factor (VEGF) expression, which in turn causes angiogenesis and increased vascular permeability. Consequently, VEGF-inhibitory treatment has been introduced in different ocular diseases. Hypoxia-inducible factor (HIF)-1α is an upstream regulator of VEGF-A, and increased HIF-1α expression has been established in ocular animal models. Upcoming translational studies are expected to increase our understanding of the complex balance between pro- and anti-angiogenic factors in the eye.",

keywords = "Angiogenesis Inducing Agents, Animals, Vascular Endothelial Growth Factor A",

author = "Yousif Subhi and Cehofski, \{Lasse J{\o}rgensen\} and Vestergaard, \{Anders H{\o}jslet\} and S{\o}rensen, \{Torben Lykke\} and Jakob Grauslund",

year = "2020",

month = oct,

day = "26",

language = "Dansk",

volume = "182",

journal = "Ugeskrift for Laeger",

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TY - JOUR

T1 - Pathological and therapeutic possibilities in inhibiting ocular angionesis

AU - Subhi, Yousif

AU - Cehofski, Lasse Jørgensen

AU - Vestergaard, Anders Højslet

AU - Sørensen, Torben Lykke

AU - Grauslund, Jakob

PY - 2020/10/26

Y1 - 2020/10/26

N2 - In a variety of corneal and retinal diseases, ocular ischaemia mediates vascular endothelial growth factor (VEGF) expression, which in turn causes angiogenesis and increased vascular permeability. Consequently, VEGF-inhibitory treatment has been introduced in different ocular diseases. Hypoxia-inducible factor (HIF)-1α is an upstream regulator of VEGF-A, and increased HIF-1α expression has been established in ocular animal models. Upcoming translational studies are expected to increase our understanding of the complex balance between pro- and anti-angiogenic factors in the eye.

AB - In a variety of corneal and retinal diseases, ocular ischaemia mediates vascular endothelial growth factor (VEGF) expression, which in turn causes angiogenesis and increased vascular permeability. Consequently, VEGF-inhibitory treatment has been introduced in different ocular diseases. Hypoxia-inducible factor (HIF)-1α is an upstream regulator of VEGF-A, and increased HIF-1α expression has been established in ocular animal models. Upcoming translational studies are expected to increase our understanding of the complex balance between pro- and anti-angiogenic factors in the eye.

KW - Angiogenesis Inducing Agents

KW - Animals

KW - Vascular Endothelial Growth Factor A

UR - https://www.scopus.com/pages/publications/85094933482

M3 - Tidsskriftartikel

C2 - 33118489

SN - 0041-5782

VL - 182

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 44

ER -

Pathological and therapeutic possibilities in inhibiting ocular angionesis

Abstract

Emneord

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