Paternal alcoholism predicts the occurrence but not the remission of alcoholic drinking: a 40-year follow-up

J Knop; E C Penick; E J Nickel; S A Mednick; P Jensen; A M Manzardo; W F Gabrielli

doi:10.1111/j.1600-0447.2007.01015.x

Paternal alcoholism predicts the occurrence but not the remission of alcoholic drinking: a 40-year follow-up

J Knop, E C Penick, E J Nickel, S A Mednick, P Jensen, A M Manzardo, W F Gabrielli

12 Citationer (Scopus)

Abstract

OBJECTIVE: To test the effects of father's alcoholism on the development and remission from alcoholic drinking by age 40.

METHOD: Subjects were selected from a Danish birth cohort that included 223 sons of alcoholic fathers (high risk; HR) and 106 matched controls (low risk; LR). Clinical examinations were performed at age 40 (n = 202) by a psychiatrist using structured interviews and DSM-III-R diagnostic criteria.

RESULTS: HR subjects were significantly more likely than LR subjects to develop alcohol dependence (31% vs. 16%), but not alcohol abuse (17% vs. 15%). More subjects with alcohol abuse were in remission at age 40 than subjects with alcohol dependence. Risk did not predict remission from either alcohol abuse or alcohol dependence.

CONCLUSION: Familial influences may play a stronger role in the development of alcoholism than in the remission or recovery from alcoholism.

Originalsprog	Engelsk
Tidsskrift	Acta Psychiatrica Scandinavica
Vol/bind	116
Udgave nummer	5
Sider (fra-til)	386-93
Antal sider	8
ISSN	0001-690X
DOI	https://doi.org/10.1111/j.1600-0447.2007.01015.x
Status	Udgivet - nov. 2007

Adgang til dokumentet

10.1111/j.1600-0447.2007.01015.x

Citationsformater

@article{e1809e384b0a4e5f98a2f71e2bafd22e,

title = "Paternal alcoholism predicts the occurrence but not the remission of alcoholic drinking: a 40-year follow-up",

abstract = "OBJECTIVE: To test the effects of father's alcoholism on the development and remission from alcoholic drinking by age 40.METHOD: Subjects were selected from a Danish birth cohort that included 223 sons of alcoholic fathers (high risk; HR) and 106 matched controls (low risk; LR). Clinical examinations were performed at age 40 (n = 202) by a psychiatrist using structured interviews and DSM-III-R diagnostic criteria.RESULTS: HR subjects were significantly more likely than LR subjects to develop alcohol dependence (31% vs. 16%), but not alcohol abuse (17% vs. 15%). More subjects with alcohol abuse were in remission at age 40 than subjects with alcohol dependence. Risk did not predict remission from either alcohol abuse or alcohol dependence.CONCLUSION: Familial influences may play a stronger role in the development of alcoholism than in the remission or recovery from alcoholism.",

keywords = "Adult, Alcohol Drinking, Alcoholism, Child, Child of Impaired Parents, Cohort Studies, Cross-Sectional Studies, Denmark, Humans, Longitudinal Studies, Male, Phenotype, Risk Factors, Temperance, Treatment Outcome",

author = "J Knop and Penick, {E C} and Nickel, {E J} and Mednick, {S A} and P Jensen and Manzardo, {A M} and Gabrielli, {W F}",

year = "2007",

month = nov,

doi = "10.1111/j.1600-0447.2007.01015.x",

language = "English",

volume = "116",

pages = "386--93",

journal = "Acta Psychiatrica Scandinavica",

issn = "0001-690X",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "5",

}

TY - JOUR

T1 - Paternal alcoholism predicts the occurrence but not the remission of alcoholic drinking

T2 - a 40-year follow-up

AU - Knop, J

AU - Penick, E C

AU - Nickel, E J

AU - Mednick, S A

AU - Jensen, P

AU - Manzardo, A M

AU - Gabrielli, W F

PY - 2007/11

Y1 - 2007/11

N2 - OBJECTIVE: To test the effects of father's alcoholism on the development and remission from alcoholic drinking by age 40.METHOD: Subjects were selected from a Danish birth cohort that included 223 sons of alcoholic fathers (high risk; HR) and 106 matched controls (low risk; LR). Clinical examinations were performed at age 40 (n = 202) by a psychiatrist using structured interviews and DSM-III-R diagnostic criteria.RESULTS: HR subjects were significantly more likely than LR subjects to develop alcohol dependence (31% vs. 16%), but not alcohol abuse (17% vs. 15%). More subjects with alcohol abuse were in remission at age 40 than subjects with alcohol dependence. Risk did not predict remission from either alcohol abuse or alcohol dependence.CONCLUSION: Familial influences may play a stronger role in the development of alcoholism than in the remission or recovery from alcoholism.

AB - OBJECTIVE: To test the effects of father's alcoholism on the development and remission from alcoholic drinking by age 40.METHOD: Subjects were selected from a Danish birth cohort that included 223 sons of alcoholic fathers (high risk; HR) and 106 matched controls (low risk; LR). Clinical examinations were performed at age 40 (n = 202) by a psychiatrist using structured interviews and DSM-III-R diagnostic criteria.RESULTS: HR subjects were significantly more likely than LR subjects to develop alcohol dependence (31% vs. 16%), but not alcohol abuse (17% vs. 15%). More subjects with alcohol abuse were in remission at age 40 than subjects with alcohol dependence. Risk did not predict remission from either alcohol abuse or alcohol dependence.CONCLUSION: Familial influences may play a stronger role in the development of alcoholism than in the remission or recovery from alcoholism.

KW - Adult

KW - Alcohol Drinking

KW - Alcoholism

KW - Child

KW - Child of Impaired Parents

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - Denmark

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Phenotype

KW - Risk Factors

KW - Temperance

KW - Treatment Outcome

U2 - 10.1111/j.1600-0447.2007.01015.x

DO - 10.1111/j.1600-0447.2007.01015.x

M3 - Journal article

C2 - 17919158

VL - 116

SP - 386

EP - 393

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 5

ER -

Paternal alcoholism predicts the occurrence but not the remission of alcoholic drinking: a 40-year follow-up

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater