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Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men

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  • Emma C E Meessen
  • Guido J Bakker
  • Max Nieuwdorp
  • Geesje M Dallinga-Thie
  • E Marleen Kemper
  • Steven W Olde Damink
  • Johannes A Romijn
  • Bolette Hartmann
  • Jens J Holst
  • Filip K Knop
  • Albert K Groen
  • Frank G Schaap
  • Maarten R Soeters
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BACKGROUND & AIMS: To investigate the acute effects of intravenous vs enteral meal administration on circulating bile acid and gut hormone responses.

METHODS: In a randomized crossover design, we compared the effects of duodenal (via a nasoduodenal tube) vs parenteral (intravenous) administration over 180 min of identical mixed meals on circulating bile acid and gut hormone concentrations in eight healthy lean men. We analysed the bile acid and gut hormone responses in two periods: the intraprandial period from time point (T) 0 until T180 during meal administration and the postprandial period from T180 until T360, after discontinuation of meal administration.

RESULTS: Intravenous meal administration decreased the intraprandial (AUC (μmol/L∗min) duodenal 1469 ± 284 vs intravenous 240 ± 39, p < 0.01) and postprandial bile acid response (985 ± 240 vs 223 ± 5, p < 0.05) and was accompanied by decreased gut hormone responses including glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, glucagon-like peptide 2 and fibroblast growth factor 19. Furthermore, intravenous meal administration elicited greater glucose concentrations, but similar insulin concentrations compared to enteral administration.

CONCLUSIONS: Compared to enteral administration, parenteral nutrition results in lower postprandial bile acid and gut hormone responses in healthy lean men. This was accompanied by higher glucose concentrations in the face of similar insulin concentrations exposing a clear incretin effect of enteral mixed meal administration. The alterations in bile acid homeostasis were apparent after only one intravenous meal.

OriginalsprogEngelsk
TidsskriftClinical nutrition (Edinburgh, Scotland)
Vol/bind40
Udgave nummer3
Sider (fra-til)1013-1021
Antal sider9
ISSN0261-5614
DOI
StatusUdgivet - mar. 2021

Bibliografisk note

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

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