Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Parental alcohol use disorder with and without other mental disorders and offspring alcohol use disorder

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Trajectory of cognitive functions in bipolar disorder: for better or worse?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Incidence of suicidal behaviour and violent crime following antidepressant medication: a Danish cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Response to comment on Osler et al: misinterpretation of pre- and post differences invalidate the authors' conclusion

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  4. Societal costs of Borderline Personality Disorders: a matched-controlled nationwide study of patients and spouses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Meta-analysis of antidepressant effects of anti-inflammatory drugs-reply

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  1. Young adult predictors of alcohol dependence to age 53: A 44-year prospective cohort study of Danish men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Self-rated worry is associated with hospital admission in out-of-hours telephone triage - a prospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: To examine the association between parental alcohol use disorder (AUD) with and without other mental disorders and offspring AUD.

METHODS: Using data from Danish nationwide registers, we identified 15 477 offspring with parental AUD and 154 392 reference individuals from the general population. Parental AUD was defined as registration for AUD treatment. Parental mental disorders were identified in medical registers and comprised psychotic, mood, anxiety, personality, drug use, and other non-alcohol-related mental disorders. AUD in offspring was identified from medical, pharmacy, treatment and cause of death registers. Hazard ratios (HRs) of AUD were estimated using Cox regression models.

RESULTS: AUD in one or both parents was associated with higher risks of AUD in offspring compared with reference individuals. Paternal AUD plus other mental disorder (HR = 2.27, 95% confidence interval (CI): 2.10-2.46) and paternal AUD alone (HR = 2.21, 95% CI: 2.07-2.36) were associated with higher offspring AUD risk. Similarly, maternal AUD plus other mental disorder (HR = 3.02, 95% CI: 2.66-3.43) and maternal AUD alone (HR = 2.57, 95% CI: 2.20-3.01) were associated with higher offspring AUD risk.

CONCLUSIONS: Offspring with parental AUD are at increased risk of AUD irrespective of exposure to other parental mental disorders.

OriginalsprogEngelsk
TidsskriftActa Psychiatrica Scandinavica
Vol/bind139
Udgave nummer6
Sider (fra-til)508-517
Antal sider10
ISSN0001-690X
DOI
StatusUdgivet - jun. 2019

Bibliografisk note

© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

ID: 56813189