Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age

Helle R Andersen; Christine Wohlfahrt Veje; Christine Dalgård; Lene Trelle Christiansen; Katharina M Main; Christine Lydia Nellemann; Katsuyuki Murata; Tina K Jensen; Niels E Skakkebæk; Philippe Grandjean

doi:10.1371/journal.pone.0036830

Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age

Helle R Andersen, Christine Wohlfahrt Veje, Christine Dalgård, Lene Trelle Christiansen, Katharina M Main, Christine Lydia Nellemann, Katsuyuki Murata, Tina K Jensen, Niels E Skakkebæk, Philippe Grandjean

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Abstract

Prenatal environmental factors might influence the risk of developing cardiovascular disease later in life. The HDL-associated enzyme paraoxonase 1 (PON1) has anti-oxidative functions that may protect against atherosclerosis. It also hydrolyzes many substrates, including organophosphate pesticides. A common polymorphism, PON1 Q192R, affects both properties, but a potential interaction between PON1 genotype and pesticide exposure on cardiovascular risk factors has not been investigated. We explored if the PON1 Q192R genotype affects cardiovascular risk factors in school-age children prenatally exposed to pesticides.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	7
Udgave nummer	5
Sider (fra-til)	e36830
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0036830
Status	Udgivet - 2012

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10.1371/journal.pone.0036830

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abstract = "Prenatal environmental factors might influence the risk of developing cardiovascular disease later in life. The HDL-associated enzyme paraoxonase 1 (PON1) has anti-oxidative functions that may protect against atherosclerosis. It also hydrolyzes many substrates, including organophosphate pesticides. A common polymorphism, PON1 Q192R, affects both properties, but a potential interaction between PON1 genotype and pesticide exposure on cardiovascular risk factors has not been investigated. We explored if the PON1 Q192R genotype affects cardiovascular risk factors in school-age children prenatally exposed to pesticides.",

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T1 - Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age

AU - Andersen, Helle R

AU - Veje, Christine Wohlfahrt

AU - Dalgård, Christine

AU - Christiansen, Lene Trelle

AU - Main, Katharina M

AU - Nellemann, Christine Lydia

AU - Murata, Katsuyuki

AU - Jensen, Tina K

AU - Skakkebæk, Niels E

AU - Grandjean, Philippe

PY - 2012

Y1 - 2012

N2 - Prenatal environmental factors might influence the risk of developing cardiovascular disease later in life. The HDL-associated enzyme paraoxonase 1 (PON1) has anti-oxidative functions that may protect against atherosclerosis. It also hydrolyzes many substrates, including organophosphate pesticides. A common polymorphism, PON1 Q192R, affects both properties, but a potential interaction between PON1 genotype and pesticide exposure on cardiovascular risk factors has not been investigated. We explored if the PON1 Q192R genotype affects cardiovascular risk factors in school-age children prenatally exposed to pesticides.

AB - Prenatal environmental factors might influence the risk of developing cardiovascular disease later in life. The HDL-associated enzyme paraoxonase 1 (PON1) has anti-oxidative functions that may protect against atherosclerosis. It also hydrolyzes many substrates, including organophosphate pesticides. A common polymorphism, PON1 Q192R, affects both properties, but a potential interaction between PON1 genotype and pesticide exposure on cardiovascular risk factors has not been investigated. We explored if the PON1 Q192R genotype affects cardiovascular risk factors in school-age children prenatally exposed to pesticides.

U2 - 10.1371/journal.pone.0036830

DO - 10.1371/journal.pone.0036830

M3 - Journal article

C2 - 22615820

SN - 1932-6203

VL - 7

SP - e36830

JO - P L o S One

JF - P L o S One

IS - 5

ER -

Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age

Abstract

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