Pancreatic somatostatinoma. Clinical features and physiological implications

L I Larsson; M A Hirsch; J J Holst; S Ingemansson; C Kühl; S L Jensen; G Lundqvist; J F Rehfeld; T W Schwartz

doi:10.1016/s0140-6736(77)92113-4

Pancreatic somatostatinoma. Clinical features and physiological implications

L I Larsson, M A Hirsch, J J Holst, S Ingemansson, C Kühl, S L Jensen, G Lundqvist, J F Rehfeld, T W Schwartz

260 Citationer (Scopus)

Abstract

The first case of a tumour producing somatostatin-like immunoreactivity and bioactivity is presented. The pancreatic tumour was composed of cells indistinguishable from islet D cells. Radioimmunoassay of blood-samples obtained by tumour-vein catheterisation revealed very high levels of somatostatin immunoreactivity. On gel chromatography tumour extracts were found to contain at least 4 different immunoreactive components, one of which eluted in the position of synthetic somatostatin. Extracts from the tumour were potent in inhibiting insulin and glucagon secretion from isolated perfused porcine pancreas. Clinical abnormalities included hypochlorhydria, steatorrhoea, and diabetic glucose tolerance. Conceivably some of these abnormalities may be related to somatostatin hypersecretion from the pancreatic tumour.

Originalsprog	Engelsk
Tidsskrift	Lancet
Vol/bind	1
Udgave nummer	8013
Sider (fra-til)	666-8
Antal sider	3
ISSN	0140-6736
DOI	https://doi.org/10.1016/s0140-6736(77)92113-4
Status	Udgivet - 26 mar. 1977
Udgivet eksternt	Ja

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10.1016/s0140-6736(77)92113-4

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title = "Pancreatic somatostatinoma. Clinical features and physiological implications",

abstract = "The first case of a tumour producing somatostatin-like immunoreactivity and bioactivity is presented. The pancreatic tumour was composed of cells indistinguishable from islet D cells. Radioimmunoassay of blood-samples obtained by tumour-vein catheterisation revealed very high levels of somatostatin immunoreactivity. On gel chromatography tumour extracts were found to contain at least 4 different immunoreactive components, one of which eluted in the position of synthetic somatostatin. Extracts from the tumour were potent in inhibiting insulin and glucagon secretion from isolated perfused porcine pancreas. Clinical abnormalities included hypochlorhydria, steatorrhoea, and diabetic glucose tolerance. Conceivably some of these abnormalities may be related to somatostatin hypersecretion from the pancreatic tumour.",

keywords = "Antigen-Antibody Reactions, Chromatography, Gel, Female, Glucagon/antagonists & inhibitors, Hormones, Ectopic/metabolism, Humans, Insulin Antagonists, Islets of Langerhans/ultrastructure, Microscopy, Electron, Middle Aged, Pancreatic Neoplasms/metabolism, Somatostatin/immunology, Staining and Labeling/methods, Tissue Extracts/analysis",

author = "Larsson, {L I} and Hirsch, {M A} and Holst, {J J} and S Ingemansson and C K{\"u}hl and Jensen, {S L} and G Lundqvist and Rehfeld, {J F} and Schwartz, {T W}",

year = "1977",

month = mar,

day = "26",

doi = "10.1016/s0140-6736(77)92113-4",

language = "English",

volume = "1",

pages = "666--8",

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number = "8013",

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TY - JOUR

T1 - Pancreatic somatostatinoma. Clinical features and physiological implications

AU - Larsson, L I

AU - Hirsch, M A

AU - Holst, J J

AU - Ingemansson, S

AU - Kühl, C

AU - Jensen, S L

AU - Lundqvist, G

AU - Rehfeld, J F

AU - Schwartz, T W

PY - 1977/3/26

Y1 - 1977/3/26

N2 - The first case of a tumour producing somatostatin-like immunoreactivity and bioactivity is presented. The pancreatic tumour was composed of cells indistinguishable from islet D cells. Radioimmunoassay of blood-samples obtained by tumour-vein catheterisation revealed very high levels of somatostatin immunoreactivity. On gel chromatography tumour extracts were found to contain at least 4 different immunoreactive components, one of which eluted in the position of synthetic somatostatin. Extracts from the tumour were potent in inhibiting insulin and glucagon secretion from isolated perfused porcine pancreas. Clinical abnormalities included hypochlorhydria, steatorrhoea, and diabetic glucose tolerance. Conceivably some of these abnormalities may be related to somatostatin hypersecretion from the pancreatic tumour.

AB - The first case of a tumour producing somatostatin-like immunoreactivity and bioactivity is presented. The pancreatic tumour was composed of cells indistinguishable from islet D cells. Radioimmunoassay of blood-samples obtained by tumour-vein catheterisation revealed very high levels of somatostatin immunoreactivity. On gel chromatography tumour extracts were found to contain at least 4 different immunoreactive components, one of which eluted in the position of synthetic somatostatin. Extracts from the tumour were potent in inhibiting insulin and glucagon secretion from isolated perfused porcine pancreas. Clinical abnormalities included hypochlorhydria, steatorrhoea, and diabetic glucose tolerance. Conceivably some of these abnormalities may be related to somatostatin hypersecretion from the pancreatic tumour.

KW - Antigen-Antibody Reactions

KW - Chromatography, Gel

KW - Female

KW - Glucagon/antagonists & inhibitors

KW - Hormones, Ectopic/metabolism

KW - Humans

KW - Insulin Antagonists

KW - Islets of Langerhans/ultrastructure

KW - Microscopy, Electron

KW - Middle Aged

KW - Pancreatic Neoplasms/metabolism

KW - Somatostatin/immunology

KW - Staining and Labeling/methods

KW - Tissue Extracts/analysis

U2 - 10.1016/s0140-6736(77)92113-4

DO - 10.1016/s0140-6736(77)92113-4

M3 - Journal article

C2 - 66472

SN - 0140-6736

VL - 1

SP - 666

EP - 668

JO - Lancet

JF - Lancet

IS - 8013

ER -

Pancreatic somatostatinoma. Clinical features and physiological implications

Abstract

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