Pancreatic β-cell function increases in a linear dose-response manner following exercise training in adults with prediabetes

Steven K Malin, Thomas P J Solomon, Alecia Blaszczak, Stephen Finnegan, Julianne Filion, John P Kirwan

    69 Citationer (Scopus)

    Abstrakt

    Although some studies suggest that a linear dose-response relationship exists between exercise and insulin sensitivity, the exercise dose required to enhance pancreatic β-cell function is unknown. Thirty-five older obese adults with prediabetes underwent a progressive 12-wk supervised exercise intervention (5 days/wk for 60 min at ~85% HRmax). Insulin and C-peptide responses to an OGTT were used to define the first- and second-phase disposition index (DI; β-cell function = glucose-stimulated insulin secretion × clamp-derived insulin sensitivity). Maximum oxygen consumption (Vo2max) and body composition (dual-energy X-ray absorptiometry and computed tomography) were also measured before and after the intervention. Exercise dose was computed using Vo2/heart-rate derived linear regression equations. Subjects expended 474.5 ± 8.8 kcal/session (2,372.5 ± 44.1 kcal/wk) during the intervention and lost ~8% body weight. Exercise increased first- and second-phase DI (P 2,000 kcal/wk) are necessary to enhance β-cell function in adults with poor insulin secretion capacity.
    OriginalsprogEngelsk
    TidsskriftAmerican Journal of Physiology: Endocrinology and Metabolism
    Vol/bind305
    Udgave nummer10
    Sider (fra-til)E1248-54
    ISSN0193-1849
    DOI
    StatusUdgivet - 15 nov. 2013

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