TY - JOUR
T1 - Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy
AU - Siopi, Maria
AU - Papadopoulos, Antonios
AU - Spiliopoulou, Anastasia
AU - Paliogianni, Fotini
AU - Abou-Chakra, Nissrine
AU - Arendrup, Maiken Cavling
AU - Damoulari, Christina
AU - Tsioulos, Georgios
AU - Giannitsioti, Efthymia
AU - Frantzeskaki, Frantzeska
AU - Tsangaris, Iraklis
AU - Pournaras, Spyros
AU - Meletiadis, Joseph
PY - 2022/9/1
Y1 - 2022/9/1
N2 - The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1−2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1.
AB - The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1−2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1.
UR - http://www.scopus.com/inward/record.url?scp=85138616692&partnerID=8YFLogxK
U2 - 10.3390/jof8090931
DO - 10.3390/jof8090931
M3 - Journal article
C2 - 36135656
SN - 2309-608X
VL - 8
SP - 1
EP - 7
JO - Journal of fungi (Basel, Switzerland)
JF - Journal of fungi (Basel, Switzerland)
IS - 9
M1 - 931
ER -