P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs

Oana Ciofu; Helle Krogh Johansen; Kasper Aanaes; Tina Wassermann; Morten Alhede; Christian von Buchwald; Niels Høiby

doi:10.1016/j.jcf.2013.02.004

P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs

Oana Ciofu, Helle Krogh Johansen, Kasper Aanaes, Tina Wassermann, Morten Alhede, Christian von Buchwald, Niels Høiby

64 Citationer (Scopus)

Abstract

Pseudomonas aeruginosa cells are present as biofilms in the paranasal sinuses and the lungs of chronically infected cystic fibrosis (CF) patients. Since different inflammatory responses and selective antibiotic pressures are acting in the sinuses compared with the lungs, we compared the adaptive profiles of mucoid and non-mucoid isolates from the two locations.

Originalsprog	Engelsk
Tidsskrift	Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Vol/bind	12
Udgave nummer	6
Sider (fra-til)	729-36
Antal sider	8
ISSN	1569-1993
DOI	https://doi.org/10.1016/j.jcf.2013.02.004
Status	Udgivet - dec. 2013

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10.1016/j.jcf.2013.02.004

Citationsformater

Ciofu, O., Johansen, H. K., Aanaes, K., Wassermann, T., Alhede, M., von Buchwald, C., & Høiby, N. (2013). P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 12(6), 729-36. https://doi.org/10.1016/j.jcf.2013.02.004

P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs. / Ciofu, Oana; Johansen, Helle Krogh ; Aanaes, Kasper et al.
I: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, Bind 12, Nr. 6, 12.2013, s. 729-36.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Ciofu, O, Johansen, HK , Aanaes, K, Wassermann, T, Alhede, M, von Buchwald, C & Høiby, N 2013, 'P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs', Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, bind 12, nr. 6, s. 729-36. https://doi.org/10.1016/j.jcf.2013.02.004

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abstract = "Pseudomonas aeruginosa cells are present as biofilms in the paranasal sinuses and the lungs of chronically infected cystic fibrosis (CF) patients. Since different inflammatory responses and selective antibiotic pressures are acting in the sinuses compared with the lungs, we compared the adaptive profiles of mucoid and non-mucoid isolates from the two locations.",

author = "Oana Ciofu and Johansen, {Helle Krogh} and Kasper Aanaes and Tina Wassermann and Morten Alhede and {von Buchwald}, Christian and Niels H{\o}iby",

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AU - Ciofu, Oana

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AU - Wassermann, Tina

AU - Alhede, Morten

AU - von Buchwald, Christian

AU - Høiby, Niels

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AB - Pseudomonas aeruginosa cells are present as biofilms in the paranasal sinuses and the lungs of chronically infected cystic fibrosis (CF) patients. Since different inflammatory responses and selective antibiotic pressures are acting in the sinuses compared with the lungs, we compared the adaptive profiles of mucoid and non-mucoid isolates from the two locations.

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P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs

Abstract

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