TY - JOUR
T1 - Oxytocin response to food intake in avoidant/restrictive food intake disorder
AU - Aulinas, Anna
AU - Muhammed, Maged
AU - Becker, Kendra R
AU - Asanza, Elisa
AU - Hauser, Kristine
AU - Stern, Casey
AU - Gydus, Julia
AU - Holmes, Tara
AU - Murray, Helen Burton
AU - Breithaupt, Lauren
AU - Micali, Nadia
AU - Misra, Madhusmita
AU - Eddy, Kamryn T
AU - Thomas, Jennifer J
AU - Lawson, Elizabeth A
N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of European Society of Endocrinology. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2023/8/2
Y1 - 2023/8/2
N2 - OBJECTIVE: To investigate the response of anorexigenic oxytocin to food intake among adolescents and young adults with avoidant/restrictive food intake disorder (ARFID), a restrictive eating disorder characterized by lack of interest in food or eating, sensory sensitivity to food, and/or fear of aversive consequences of eating, compared with healthy controls (HC).DESIGN: Cross-sectional.METHODS: A total of 109 participants (54 with ARFID spectrum and 55 HC) were instructed to eat a ∼400-kcal standardized mixed meal. We sampled serum oxytocin at fasting and at 30-, 60-, and 120-min postmeal. We tested the hypothesis that ARFID would show higher mean oxytocin levels across time points compared with HC using a mixed model ANOVA. We then used multivariate regression analysis to identify the impact of clinical characteristics (sex, age, and body mass index [BMI] percentile) on oxytocin levels in individuals with ARFID.RESULTS: Participants with ARFID exhibited greater mean oxytocin levels at all time points compared with HC, and these differences remained significant even after controlling for sex and BMI percentile (P = .004). Clinical variables (sex, age, and BMI percentile) did not show any impact on fasting and postprandial oxytocin levels among individuals with ARFID.CONCLUSIONS: Consistently high oxytocin levels might be involved in low appetite and sensory aversions to food, contributing to food avoidance in individuals with ARFID.
AB - OBJECTIVE: To investigate the response of anorexigenic oxytocin to food intake among adolescents and young adults with avoidant/restrictive food intake disorder (ARFID), a restrictive eating disorder characterized by lack of interest in food or eating, sensory sensitivity to food, and/or fear of aversive consequences of eating, compared with healthy controls (HC).DESIGN: Cross-sectional.METHODS: A total of 109 participants (54 with ARFID spectrum and 55 HC) were instructed to eat a ∼400-kcal standardized mixed meal. We sampled serum oxytocin at fasting and at 30-, 60-, and 120-min postmeal. We tested the hypothesis that ARFID would show higher mean oxytocin levels across time points compared with HC using a mixed model ANOVA. We then used multivariate regression analysis to identify the impact of clinical characteristics (sex, age, and body mass index [BMI] percentile) on oxytocin levels in individuals with ARFID.RESULTS: Participants with ARFID exhibited greater mean oxytocin levels at all time points compared with HC, and these differences remained significant even after controlling for sex and BMI percentile (P = .004). Clinical variables (sex, age, and BMI percentile) did not show any impact on fasting and postprandial oxytocin levels among individuals with ARFID.CONCLUSIONS: Consistently high oxytocin levels might be involved in low appetite and sensory aversions to food, contributing to food avoidance in individuals with ARFID.
KW - avoidant/restrictive food intake disorder
KW - feeding and eating disorders
KW - food control
KW - hypothalamus
KW - oxytocin
UR - http://www.scopus.com/inward/record.url?scp=85166442665&partnerID=8YFLogxK
U2 - 10.1093/ejendo/lvad087
DO - 10.1093/ejendo/lvad087
M3 - Journal article
C2 - 37474111
SN - 0804-4643
VL - 189
SP - 149
EP - 155
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
IS - 2
ER -