Oxytocin response to food intake in avoidant/restrictive food intake disorder

Anna Aulinas, Maged Muhammed, Kendra R Becker, Elisa Asanza, Kristine Hauser, Casey Stern, Julia Gydus, Tara Holmes, Helen Burton Murray, Lauren Breithaupt, Nadia Micali, Madhusmita Misra, Kamryn T Eddy, Jennifer J Thomas, Elizabeth A Lawson

3 Citationer (Scopus)

Abstract

OBJECTIVE: To investigate the response of anorexigenic oxytocin to food intake among adolescents and young adults with avoidant/restrictive food intake disorder (ARFID), a restrictive eating disorder characterized by lack of interest in food or eating, sensory sensitivity to food, and/or fear of aversive consequences of eating, compared with healthy controls (HC).

DESIGN: Cross-sectional.

METHODS: A total of 109 participants (54 with ARFID spectrum and 55 HC) were instructed to eat a ∼400-kcal standardized mixed meal. We sampled serum oxytocin at fasting and at 30-, 60-, and 120-min postmeal. We tested the hypothesis that ARFID would show higher mean oxytocin levels across time points compared with HC using a mixed model ANOVA. We then used multivariate regression analysis to identify the impact of clinical characteristics (sex, age, and body mass index [BMI] percentile) on oxytocin levels in individuals with ARFID.

RESULTS: Participants with ARFID exhibited greater mean oxytocin levels at all time points compared with HC, and these differences remained significant even after controlling for sex and BMI percentile (P = .004). Clinical variables (sex, age, and BMI percentile) did not show any impact on fasting and postprandial oxytocin levels among individuals with ARFID.

CONCLUSIONS: Consistently high oxytocin levels might be involved in low appetite and sensory aversions to food, contributing to food avoidance in individuals with ARFID.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Endocrinology
Vol/bind189
Udgave nummer2
Sider (fra-til)149-155
Antal sider7
ISSN0804-4643
DOI
StatusUdgivet - 2 aug. 2023

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