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Oxytocin receptor blockade: a new principle in the treatment of preterm labor?

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Harvard

Andersen, LF, Lyndrup, J, Akerlund, M & Melin, P 1989, 'Oxytocin receptor blockade: a new principle in the treatment of preterm labor?' American Journal of Perinatology, bind 6, nr. 2, s. 196-199.

APA

Andersen, L. F., Lyndrup, J., Akerlund, M., & Melin, P. (1989). Oxytocin receptor blockade: a new principle in the treatment of preterm labor? American Journal of Perinatology, 6(2), 196-199.

CBE

MLA

Vancouver

Author

Andersen, L F ; Lyndrup, J ; Akerlund, M ; Melin, P. / Oxytocin receptor blockade: a new principle in the treatment of preterm labor?. I: American Journal of Perinatology. 1989 ; Bind 6, Nr. 2. s. 196-199.

Bibtex

@article{e7fdf8a89c1849a592bf9e1df806c3aa,
title = "Oxytocin receptor blockade: a new principle in the treatment of preterm labor?",
abstract = "The concentration of myometrial and decidual oxytocin receptors increases dramatically in normal women in late pregnancy, causing enhanced uterine sensitivity to physiologic levels of oxytocin. Similar increase in myometrial oxytocin receptors has been found in women in preterm labor, indicating a role for oxytocin also in idiopathic preterm labor. A newly synthesized oxytocin analogue, 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-oxytocin, has been found to be a competitive inhibitor of oxytocin. The present study was conducted to test its efficacy in suppressing uterine contractions during preterm labor in women. Twelve patients with established, uncomplicated preterm labor between 27 and 33 weeks of gestational age were given intravenous infusions of the analogue for 1.5 to 13 hours during continuous external cardiotocographic monitoring. In nine patients inhibition of uterine contractions was achieved and further progression in cervical scores was arrested. In three patients, all at 27 weeks of gestational age, no significant tocolytic effect was observed during a 1.5-hour infusion of the analogue and the patients were then given ritodrine intravenously. No side effects were observed in any of the patients. These preliminary findings support the concept that an increased concentration of uterine oxytocin receptors is an important etiologic factor in uncomplicated preterm labor and therefore oxytocin receptor blockade may be a therapeutic alternative for this condition.",
author = "Andersen, {L F} and J Lyndrup and M Akerlund and P Melin",
year = "1989",
language = "English",
volume = "6",
pages = "196--199",
journal = "American Journal of Perinatology",
issn = "0735-1631",
publisher = "Thieme Medical Publishers",
number = "2",

}

RIS

TY - JOUR

T1 - Oxytocin receptor blockade: a new principle in the treatment of preterm labor?

AU - Andersen, L F

AU - Lyndrup, J

AU - Akerlund, M

AU - Melin, P

PY - 1989

Y1 - 1989

N2 - The concentration of myometrial and decidual oxytocin receptors increases dramatically in normal women in late pregnancy, causing enhanced uterine sensitivity to physiologic levels of oxytocin. Similar increase in myometrial oxytocin receptors has been found in women in preterm labor, indicating a role for oxytocin also in idiopathic preterm labor. A newly synthesized oxytocin analogue, 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-oxytocin, has been found to be a competitive inhibitor of oxytocin. The present study was conducted to test its efficacy in suppressing uterine contractions during preterm labor in women. Twelve patients with established, uncomplicated preterm labor between 27 and 33 weeks of gestational age were given intravenous infusions of the analogue for 1.5 to 13 hours during continuous external cardiotocographic monitoring. In nine patients inhibition of uterine contractions was achieved and further progression in cervical scores was arrested. In three patients, all at 27 weeks of gestational age, no significant tocolytic effect was observed during a 1.5-hour infusion of the analogue and the patients were then given ritodrine intravenously. No side effects were observed in any of the patients. These preliminary findings support the concept that an increased concentration of uterine oxytocin receptors is an important etiologic factor in uncomplicated preterm labor and therefore oxytocin receptor blockade may be a therapeutic alternative for this condition.

AB - The concentration of myometrial and decidual oxytocin receptors increases dramatically in normal women in late pregnancy, causing enhanced uterine sensitivity to physiologic levels of oxytocin. Similar increase in myometrial oxytocin receptors has been found in women in preterm labor, indicating a role for oxytocin also in idiopathic preterm labor. A newly synthesized oxytocin analogue, 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-oxytocin, has been found to be a competitive inhibitor of oxytocin. The present study was conducted to test its efficacy in suppressing uterine contractions during preterm labor in women. Twelve patients with established, uncomplicated preterm labor between 27 and 33 weeks of gestational age were given intravenous infusions of the analogue for 1.5 to 13 hours during continuous external cardiotocographic monitoring. In nine patients inhibition of uterine contractions was achieved and further progression in cervical scores was arrested. In three patients, all at 27 weeks of gestational age, no significant tocolytic effect was observed during a 1.5-hour infusion of the analogue and the patients were then given ritodrine intravenously. No side effects were observed in any of the patients. These preliminary findings support the concept that an increased concentration of uterine oxytocin receptors is an important etiologic factor in uncomplicated preterm labor and therefore oxytocin receptor blockade may be a therapeutic alternative for this condition.

M3 - Journal article

VL - 6

SP - 196

EP - 199

JO - American Journal of Perinatology

JF - American Journal of Perinatology

SN - 0735-1631

IS - 2

ER -

ID: 32501078