TY - JOUR
T1 - Oxysterols and Parkinson's disease
T2 - Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease
AU - Björkhem, Ingemar
AU - Lövgren-Sandblom, Anita
AU - Leoni, Valerio
AU - Meaney, Steve
AU - Brodin, Lovisa
AU - Salvesen, Lisette
AU - Winge, Kristian
AU - Pålhagen, Sven
AU - Svenningsson, Per
N1 - Copyright © 2013. Published by Elsevier Ireland Ltd.
PY - 2013/10/25
Y1 - 2013/10/25
N2 - Oxysterols are important for cholesterol homeostasis in the brain and may be affected in neurodegenerative diseases. The levels of the brain-derived oxysterol 24S-hydroxycholesterol (24S-OH) have been reported to be markedly reduced in the circulation of patients with Parkinson's disease (PD) (Lee et al., Antioxid. Redox Signal. 11 (2009) 407-420). The finding is surprising in view of the fact that other neurodegenerative diseases are associated with relatively modest effects on the circulating levels of 24S-OH. We determined the plasma and cerebrospinal fluid (CSF) levels of 24S-OH and 27-hydroxycholesterol (27-OH) in patients with PD with different disease duration using a highly accurate method based on isotope dilution-mass spectrometry. All the patients had plasma levels of the different oxysterols within the normal range. When analyzing CSF, 10% of the PD patients were found to have levels of 24S-OH above the cut-off level and interestingly there was a significant correlation between levels of 24S-OH in CSF and duration of the disease (r=0.40, P
AB - Oxysterols are important for cholesterol homeostasis in the brain and may be affected in neurodegenerative diseases. The levels of the brain-derived oxysterol 24S-hydroxycholesterol (24S-OH) have been reported to be markedly reduced in the circulation of patients with Parkinson's disease (PD) (Lee et al., Antioxid. Redox Signal. 11 (2009) 407-420). The finding is surprising in view of the fact that other neurodegenerative diseases are associated with relatively modest effects on the circulating levels of 24S-OH. We determined the plasma and cerebrospinal fluid (CSF) levels of 24S-OH and 27-hydroxycholesterol (27-OH) in patients with PD with different disease duration using a highly accurate method based on isotope dilution-mass spectrometry. All the patients had plasma levels of the different oxysterols within the normal range. When analyzing CSF, 10% of the PD patients were found to have levels of 24S-OH above the cut-off level and interestingly there was a significant correlation between levels of 24S-OH in CSF and duration of the disease (r=0.40, P
U2 - 10.1016/j.neulet.2013.09.003
DO - 10.1016/j.neulet.2013.09.003
M3 - Journal article
C2 - 24035896
SN - 0304-3940
VL - 555
SP - 102
EP - 105
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -