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Oxygen therapy for cluster headache. A mask comparison trial. A single-blinded, placebo-controlled, crossover study

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@article{d3c6846c5b2f45e3b32d3b1159ceb3ca,
title = "Oxygen therapy for cluster headache. A mask comparison trial. A single-blinded, placebo-controlled, crossover study",
abstract = "PURPOSE: The purpose of this article is to investigate possible differences in effect between three types of masks in the acute treatment of cluster headache (CH).PATIENTS AND METHODS: Fifty-seven CH patients according to ICHD-II-criteria participated in a single-blinded, semi-randomized, placebo-controlled, crossover inpatient study, and 102 CH attacks were treated with 100{\%} oxygen delivered by demand valve oxygen (DVO), O2ptimask or simple mask (15 liters/min) or placebo delivered by DVO for 15 minutes. Primary endpoint: Two-point decrease of pain on a five-point rating scale within 15 minutes.RESULTS: Only 10 CH patients had multiple attacks and reached the point of placebo. There were no significant differences between masks in the primary endpoints (p = 0.412). After 15 minutes 48{\%} had a two-point decrease using the DVO compared to 45{\%} with placebo (p = 0.867). After 30 minutes 68{\%} were pain free or had pain relief using DVO and 45{\%} by placebo (p = 0.061). The DVO was preferred by 62{\%} compared to 5{\%} and 33{\%} for simple mask (p < 0.0001) and O2ptimask (p = 0.061). In the first attack the DVO was significantly better at achieving pain relief at 15 minutes (p = 0.018). Treatment with DVO or O2ptimask reduced the need for rescue medication compared to the simple mask (23{\%}, 19{\%}, 50{\%}, respectively). No treatment-related adverse events were observed.CONCLUSION: The primary endpoint with pain relief at 15 minutes was non-significant; however, a post hoc analysis of the first attack significantly favored DVO. Further, therapy by O2ptimask and DVO resulted in a decreased need for rescue medication. We recommend that CH patients be offered DVO or O2ptimask before oxygen therapy is abandoned.",
author = "Petersen, {Anja S} and Barloese, {Mads Cj} and Lund, {Nunu Lt} and Jensen, {Rigmor H}",
note = "{\circledC} International Headache Society 2016.",
year = "2017",
doi = "10.1177/0333102416637817",
language = "English",
volume = "37",
pages = "214--224",
journal = "Cephalalgia",
issn = "0333-1024",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Oxygen therapy for cluster headache. A mask comparison trial. A single-blinded, placebo-controlled, crossover study

AU - Petersen, Anja S

AU - Barloese, Mads Cj

AU - Lund, Nunu Lt

AU - Jensen, Rigmor H

N1 - © International Headache Society 2016.

PY - 2017

Y1 - 2017

N2 - PURPOSE: The purpose of this article is to investigate possible differences in effect between three types of masks in the acute treatment of cluster headache (CH).PATIENTS AND METHODS: Fifty-seven CH patients according to ICHD-II-criteria participated in a single-blinded, semi-randomized, placebo-controlled, crossover inpatient study, and 102 CH attacks were treated with 100% oxygen delivered by demand valve oxygen (DVO), O2ptimask or simple mask (15 liters/min) or placebo delivered by DVO for 15 minutes. Primary endpoint: Two-point decrease of pain on a five-point rating scale within 15 minutes.RESULTS: Only 10 CH patients had multiple attacks and reached the point of placebo. There were no significant differences between masks in the primary endpoints (p = 0.412). After 15 minutes 48% had a two-point decrease using the DVO compared to 45% with placebo (p = 0.867). After 30 minutes 68% were pain free or had pain relief using DVO and 45% by placebo (p = 0.061). The DVO was preferred by 62% compared to 5% and 33% for simple mask (p < 0.0001) and O2ptimask (p = 0.061). In the first attack the DVO was significantly better at achieving pain relief at 15 minutes (p = 0.018). Treatment with DVO or O2ptimask reduced the need for rescue medication compared to the simple mask (23%, 19%, 50%, respectively). No treatment-related adverse events were observed.CONCLUSION: The primary endpoint with pain relief at 15 minutes was non-significant; however, a post hoc analysis of the first attack significantly favored DVO. Further, therapy by O2ptimask and DVO resulted in a decreased need for rescue medication. We recommend that CH patients be offered DVO or O2ptimask before oxygen therapy is abandoned.

AB - PURPOSE: The purpose of this article is to investigate possible differences in effect between three types of masks in the acute treatment of cluster headache (CH).PATIENTS AND METHODS: Fifty-seven CH patients according to ICHD-II-criteria participated in a single-blinded, semi-randomized, placebo-controlled, crossover inpatient study, and 102 CH attacks were treated with 100% oxygen delivered by demand valve oxygen (DVO), O2ptimask or simple mask (15 liters/min) or placebo delivered by DVO for 15 minutes. Primary endpoint: Two-point decrease of pain on a five-point rating scale within 15 minutes.RESULTS: Only 10 CH patients had multiple attacks and reached the point of placebo. There were no significant differences between masks in the primary endpoints (p = 0.412). After 15 minutes 48% had a two-point decrease using the DVO compared to 45% with placebo (p = 0.867). After 30 minutes 68% were pain free or had pain relief using DVO and 45% by placebo (p = 0.061). The DVO was preferred by 62% compared to 5% and 33% for simple mask (p < 0.0001) and O2ptimask (p = 0.061). In the first attack the DVO was significantly better at achieving pain relief at 15 minutes (p = 0.018). Treatment with DVO or O2ptimask reduced the need for rescue medication compared to the simple mask (23%, 19%, 50%, respectively). No treatment-related adverse events were observed.CONCLUSION: The primary endpoint with pain relief at 15 minutes was non-significant; however, a post hoc analysis of the first attack significantly favored DVO. Further, therapy by O2ptimask and DVO resulted in a decreased need for rescue medication. We recommend that CH patients be offered DVO or O2ptimask before oxygen therapy is abandoned.

U2 - 10.1177/0333102416637817

DO - 10.1177/0333102416637817

M3 - Journal article

VL - 37

SP - 214

EP - 224

JO - Cephalalgia

JF - Cephalalgia

SN - 0333-1024

IS - 3

ER -

ID: 49708521