Overnight control of blood glucose in people with type 1 diabetes

Dimitri Boiroux, Anne Katrine Duun-Henriksen, Signe Schmidt, Kirsten Nørgaard, Sten Madsbad, Ole Skyggebjerg, Peter Ruhdal Jensen, Niels Kjølstad Poulsen, Henrik Madsen, John Bagterp Jørgensen*

*Corresponding author af dette arbejde
24 Citationer (Scopus)

Abstract

In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.

OriginalsprogEngelsk
TitelProceedings of the 8th IFAC Symposium on Biological and Medical Systems, BMS 2012
Antal sider6
ForlagIFAC Secretariat
Publikationsdato1 jan. 2012
Udgave18
Sider73-78
ISBN (Trykt)9783902823106
DOI
StatusUdgivet - 1 jan. 2012
Begivenhed8th IFAC Symposium on Biological and Medical Systems, BMS 2012 - Budapest, Ungarn
Varighed: 29 aug. 201231 aug. 2012

Konference

Konference8th IFAC Symposium on Biological and Medical Systems, BMS 2012
Land/OmrådeUngarn
ByBudapest
Periode29/08/201231/08/2012
NavnIFAC Proceedings Volumes (IFAC-PapersOnline)
Nummer18
Vol/bind45
ISSN1474-6670

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