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Region Hovedstaden - en del af Københavns Universitetshospital
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Ovarian Clear Cell Carcinoma: From Morphology to Molecular Biology

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  2. Archival bone marrow samples: suitable for multiple biomarker analysis

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  3. Differential Expression of miR-155 and miR-21 in Tumor and Stroma Cells in Diffuse Large B-Cell Lymphoma

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  1. Shared heritability and functional enrichment across six solid cancers

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  2. Optimized Biobanking Procedures for Preservation of RNA in Tissue: Comparison of Snap-Freezing and RNAlater-Fixation Methods

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  3. PD-L1 expression is low in large B-cell lymphoma with MYC or double-hit translocation

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  4. Publisher Correction: Shared heritability and functional enrichment across six solid cancers

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  • Giuseppina Improta
  • Angela Pettinato
  • Estrid Høgdall
  • Giuseppe Santeusanio
  • Simona Vatrano
  • Filippo Fraggetta
  • Gian Franco Zannoni
Vis graf over relationer

Ovarian clear cell carcinoma (oCCC) is a distinctive subtype of ovarian carcinoma, with peculiar genetic and environmental risk factors, precursor lesions, molecular events during oncogenesis, patterns of spread, and response to treatment. Because of low response to chemotherapy and poor prognosis in advanced stages, there is growing interest in investigating the molecular pathways involved in oCCC development, in order to individualize novel/molecular targeted therapies. Until now, the main molecular genetic changes associated with oCCC remain to be identified, and, although several molecular changes have been reported in clear cell tumors, most studies have analyzed a limited number of cases; therefore, the true prevalence of those changes is not known. The present review will present the clinicopathologic features of oCCC, from morphology to molecular biology, discussing the diagnostic and treatment challenges of this intriguing ovarian carcinoma.

OriginalsprogEngelsk
TidsskriftApplied Immunohistochemistry and Molecular Morphology
ISSN1541-2016
DOI
StatusUdgivet - okt. 2019

ID: 56644447