Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Ovarian carcinoma histotype determination is highly reproducible, and is improved through the use of immunohistochemistry

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Pitfalls of histopathological evaluation of EUS guided microbiopsies from pancreatic cystic neoplasms

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Application of automated image analysis reduces the workload of manual screening of sentinel lymph node biopsies in breast cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. TRPM4 expression is associated with activated B cell subtype and poor survival in diffuse large B cell lymphoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Gentagne diploid biparental molae

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Neuroendocrine Tumors of the Fallopian Tube: Report of a Case Series and Review of the Literature

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. The prevalence of EBV and CMV DNA in epithelial ovarian cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. A Selective Biomarker Panel Increases the Reproducibility and the Accuracy in Endometrial Biopsy Diagnosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Hybrid Capture 2 and cobas human papillomavirus assays perform similarly on SurePath samples from women with abnormalities

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Martin Köbel
  • Julia Bak
  • Björn I Bertelsen
  • Olli Carpen
  • Anni Grove
  • Estrid Stæhr Hansen
  • Anne-Marie Levin Jakobsen
  • Marianne Lidang
  • Anna Måsbäck
  • Anna Tolf
  • C Blake Gilks
  • Joseph W Carlson
Vis graf over relationer

AIMS: To assess the variation in ovarian carcinoma type diagnosis among gynaecological pathologists from Nordic countries, and whether a rationally designed panel of immunohistochemical markers could improve diagnostic reproducibility.

METHODS AND RESULTS: Eight pathologists from four countries (Sweden, Denmark, Norway, and Finland) received an educational lecture on the diagnosis of ovarian carcinoma type. All tumour-containing slides from 54 ovarian carcinoma cases were independently reviewed by the participants, who: (i) determined type purely on the basis of histology; (ii) indicated whether they would apply immunohistochemistry in their routine practice; and (iii) determined type after reviewing the staining results. The results for six markers (WT1, p53, p16, HNF-1β, ARID1A, and progesterone receptor) were determined for all 54 cases, by staining of a tissue microarray. The median concordance with central review diagnosis was 86%, and significantly improved to 90% with the incorporation of immunostaining results (P = 0.0002). The median interobserver agreement was 78%, and significantly improved to 85% with the incorporation of immunostaining results (P = 0.0002).

CONCLUSIONS: Use of the immunostaining results significantly improved both diagnostic accuracy and interobserver agreement. These results indicate that ovarian carcinoma type can be reliably diagnosed by pathologists from different countries, and also demonstrate that immunohistochemistry has an important role in improving diagnostic accuracy and agreement between pathologists.

OriginalsprogEngelsk
TidsskriftHistopathology
Vol/bind64
Udgave nummer7
Sider (fra-til)1004-13
Antal sider10
ISSN0309-0167
DOI
StatusUdgivet - jun. 2014

ID: 44381832