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Out-of-hospital cardiac arrest: 30-day survival and 1-year risk of anoxic brain damage or nursing home admission according to consciousness status at hospital arrival

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@article{bed5ee05bc5441f28e51621903e430de,
title = "Out-of-hospital cardiac arrest: 30-day survival and 1-year risk of anoxic brain damage or nursing home admission according to consciousness status at hospital arrival",
abstract = "AIM: To investigate the association between consciousness status at hospital arrival and long-term outcomes in out-of-hospital cardiac arrest (OHCA) patients.METHODS: OHCAs between 18-100 years of age were identified from the Danish Cardiac Arrest Registry during 2005-2014. Patients with return of spontaneous circulation (ROSC) or ongoing cardiopulmonary resuscitation (CPR) at hospital arrival were included. Thirty-day survival was evaluated using Kaplan-Meier estimates. Risk of anoxic brain damage or nursing home admission and return to work among 30-day survivors were evaluated using Aalen-Johansen estimates and cause-specific Cox regression.RESULTS: Upon hospital arrival of 13,953 OHCA patients, 776 (5.6{\%}) had ROSC and were conscious (Glasgow Coma Score [GCS]>8), 5,205 (37.3{\%}) had ROSC, but were comatose (GCS ≤ 8), and 7,972 (57.1{\%}) had ongoing CPR. Thirty-day survival according to status at hospital arrival among patients that were conscious, comatose, or had ongoing CPR was 89.0{\%} (95{\%} confidence interval [CI] 86.8{\%}-91.2{\%}), 39.0{\%} (95{\%} CI 37.6{\%}-40.3{\%}), and 1.2{\%} (95{\%} CI 1.0{\%}-1.4{\%}), respectively. Among 30-day survivors, 1-year risks of new onset anoxic brain damage or nursing home admission according to consciousness status were 2.4{\%} (95{\%} CI 1.2{\%}-3.6{\%}), 12.9{\%} (95{\%} CI 11.4{\%}-14.3{\%}), and 19.4{\%} (95{\%} CI 11.3{\%}-27.4{\%}), respectively. Among 30-day working-age survivors, more than 65{\%} in each group returned to work within 5 years.CONCLUSION: Consciousness status at hospital arrival was strongly associated with 30-day survival in OHCA patients. Among 30-day survivors, a minority was diagnosed with anoxic brain damage or admitted to a nursing home and the majority returned to work independent of consciousness status at hospital arrival.",
keywords = "Anoxic brain damage, Consciousness status, OHCA, Return to work, Survival",
author = "Sondergaard, {Kathrine B} and Signe Riddersholm and Mads Wissenberg and {Moller Hansen}, Steen and Barcella, {Carlo Alberto} and Lena Karlsson and Kristian Bundgaard and Lippert, {Freddy K} and Jesper Kjaergaard and Gislason, {Gunnar H} and Fredrik Folke and Christian Torp-Pedersen and Kristian Kragholm",
note = "Copyright {\circledC} 2019. Published by Elsevier B.V.",
year = "2020",
month = "3",
day = "1",
doi = "10.1016/j.resuscitation.2019.12.006",
language = "English",
volume = "148",
pages = "251--258",
journal = "Resuscitation",
issn = "0300-9572",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Out-of-hospital cardiac arrest

T2 - 30-day survival and 1-year risk of anoxic brain damage or nursing home admission according to consciousness status at hospital arrival

AU - Sondergaard, Kathrine B

AU - Riddersholm, Signe

AU - Wissenberg, Mads

AU - Moller Hansen, Steen

AU - Barcella, Carlo Alberto

AU - Karlsson, Lena

AU - Bundgaard, Kristian

AU - Lippert, Freddy K

AU - Kjaergaard, Jesper

AU - Gislason, Gunnar H

AU - Folke, Fredrik

AU - Torp-Pedersen, Christian

AU - Kragholm, Kristian

N1 - Copyright © 2019. Published by Elsevier B.V.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - AIM: To investigate the association between consciousness status at hospital arrival and long-term outcomes in out-of-hospital cardiac arrest (OHCA) patients.METHODS: OHCAs between 18-100 years of age were identified from the Danish Cardiac Arrest Registry during 2005-2014. Patients with return of spontaneous circulation (ROSC) or ongoing cardiopulmonary resuscitation (CPR) at hospital arrival were included. Thirty-day survival was evaluated using Kaplan-Meier estimates. Risk of anoxic brain damage or nursing home admission and return to work among 30-day survivors were evaluated using Aalen-Johansen estimates and cause-specific Cox regression.RESULTS: Upon hospital arrival of 13,953 OHCA patients, 776 (5.6%) had ROSC and were conscious (Glasgow Coma Score [GCS]>8), 5,205 (37.3%) had ROSC, but were comatose (GCS ≤ 8), and 7,972 (57.1%) had ongoing CPR. Thirty-day survival according to status at hospital arrival among patients that were conscious, comatose, or had ongoing CPR was 89.0% (95% confidence interval [CI] 86.8%-91.2%), 39.0% (95% CI 37.6%-40.3%), and 1.2% (95% CI 1.0%-1.4%), respectively. Among 30-day survivors, 1-year risks of new onset anoxic brain damage or nursing home admission according to consciousness status were 2.4% (95% CI 1.2%-3.6%), 12.9% (95% CI 11.4%-14.3%), and 19.4% (95% CI 11.3%-27.4%), respectively. Among 30-day working-age survivors, more than 65% in each group returned to work within 5 years.CONCLUSION: Consciousness status at hospital arrival was strongly associated with 30-day survival in OHCA patients. Among 30-day survivors, a minority was diagnosed with anoxic brain damage or admitted to a nursing home and the majority returned to work independent of consciousness status at hospital arrival.

AB - AIM: To investigate the association between consciousness status at hospital arrival and long-term outcomes in out-of-hospital cardiac arrest (OHCA) patients.METHODS: OHCAs between 18-100 years of age were identified from the Danish Cardiac Arrest Registry during 2005-2014. Patients with return of spontaneous circulation (ROSC) or ongoing cardiopulmonary resuscitation (CPR) at hospital arrival were included. Thirty-day survival was evaluated using Kaplan-Meier estimates. Risk of anoxic brain damage or nursing home admission and return to work among 30-day survivors were evaluated using Aalen-Johansen estimates and cause-specific Cox regression.RESULTS: Upon hospital arrival of 13,953 OHCA patients, 776 (5.6%) had ROSC and were conscious (Glasgow Coma Score [GCS]>8), 5,205 (37.3%) had ROSC, but were comatose (GCS ≤ 8), and 7,972 (57.1%) had ongoing CPR. Thirty-day survival according to status at hospital arrival among patients that were conscious, comatose, or had ongoing CPR was 89.0% (95% confidence interval [CI] 86.8%-91.2%), 39.0% (95% CI 37.6%-40.3%), and 1.2% (95% CI 1.0%-1.4%), respectively. Among 30-day survivors, 1-year risks of new onset anoxic brain damage or nursing home admission according to consciousness status were 2.4% (95% CI 1.2%-3.6%), 12.9% (95% CI 11.4%-14.3%), and 19.4% (95% CI 11.3%-27.4%), respectively. Among 30-day working-age survivors, more than 65% in each group returned to work within 5 years.CONCLUSION: Consciousness status at hospital arrival was strongly associated with 30-day survival in OHCA patients. Among 30-day survivors, a minority was diagnosed with anoxic brain damage or admitted to a nursing home and the majority returned to work independent of consciousness status at hospital arrival.

KW - Anoxic brain damage

KW - Consciousness status

KW - OHCA

KW - Return to work

KW - Survival

U2 - 10.1016/j.resuscitation.2019.12.006

DO - 10.1016/j.resuscitation.2019.12.006

M3 - Journal article

VL - 148

SP - 251

EP - 258

JO - Resuscitation

JF - Resuscitation

SN - 0300-9572

ER -

ID: 58719460