TY - JOUR
T1 - Outcomes of acute respiratory distress syndrome in COVID-19 patients compared to the general population
T2 - a systematic review and meta-analysis
AU - Dmytriw, Adam A
AU - Chibbar, Richa
AU - Chen, Petty Pin Yu
AU - Traynor, Michael D
AU - Kim, Dong Wook
AU - Bruno, Fernando P
AU - Cheung, Christopher C
AU - Pareek, Anuj
AU - Chou, Andrew Chia Chen
AU - Graham, Jeffrey
AU - Dibas, Mahmoud
AU - Paranjape, Geeta
AU - Reierson, Natalie L
AU - Kamrowski, Shelby
AU - Rozowsky, Jacob
AU - Barrett, Averi
AU - Schmidt, Megan
AU - Shahani, Disha
AU - Cowie, Kathryn
AU - Davis, Amber R
AU - Abdelmegeed, Mohamed
AU - Touchette, Jillienne C
AU - Kallmes, Kevin M
AU - Pederson, John M
AU - Keesari, Praneeth Reddy
PY - 2021/10
Y1 - 2021/10
N2 - INTRODUCTION: Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) often leads to mortality. Outcomes of patients with COVID-19-related ARDS compared to ARDS unrelated to COVID-19 is not well characterized.AREAS COVERED: We performed a systematic review of PubMed, Scopus, and MedRxiv 11/1/2019 to 3/1/2021, including studies comparing outcomes in COVID-19-related ARDS (COVID-19 group) and ARDS unrelated to COVID-19 (ARDS group). Outcomes investigated were duration of mechanical ventilation-free days, intensive care unit (ICU) length-of-stay (LOS), hospital LOS, and mortality. Random effects models were fit for each outcome measure. Effect sizes were reported as pooled median differences of medians (MDMs), mean differences (MDs), or odds ratios (ORs).EXPERT OPINION: Ten studies with 2,281 patients met inclusion criteria (COVID-19: 861 [37.7%], ARDS: 1420 [62.3%]). There were no significant differences between the COVID-19 and ARDS groups for median number of mechanical ventilator-free days (MDM: -7.0 [95% CI: -14.8; 0.7], p = 0.075), ICU LOS (MD: 3.1 [95% CI: -5.9; 12.1], p = 0.501), hospital LOS (MD: 2.5 [95% CI: -5.6; 10.7], p = 0.542), or all-cause mortality (OR: 1.25 [95% CI: 0.78; 1.99], p = 0.361). Compared to the general ARDS population, results did not suggest worse outcomes in COVID-19-related ARDS.
AB - INTRODUCTION: Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) often leads to mortality. Outcomes of patients with COVID-19-related ARDS compared to ARDS unrelated to COVID-19 is not well characterized.AREAS COVERED: We performed a systematic review of PubMed, Scopus, and MedRxiv 11/1/2019 to 3/1/2021, including studies comparing outcomes in COVID-19-related ARDS (COVID-19 group) and ARDS unrelated to COVID-19 (ARDS group). Outcomes investigated were duration of mechanical ventilation-free days, intensive care unit (ICU) length-of-stay (LOS), hospital LOS, and mortality. Random effects models were fit for each outcome measure. Effect sizes were reported as pooled median differences of medians (MDMs), mean differences (MDs), or odds ratios (ORs).EXPERT OPINION: Ten studies with 2,281 patients met inclusion criteria (COVID-19: 861 [37.7%], ARDS: 1420 [62.3%]). There were no significant differences between the COVID-19 and ARDS groups for median number of mechanical ventilator-free days (MDM: -7.0 [95% CI: -14.8; 0.7], p = 0.075), ICU LOS (MD: 3.1 [95% CI: -5.9; 12.1], p = 0.501), hospital LOS (MD: 2.5 [95% CI: -5.6; 10.7], p = 0.542), or all-cause mortality (OR: 1.25 [95% CI: 0.78; 1.99], p = 0.361). Compared to the general ARDS population, results did not suggest worse outcomes in COVID-19-related ARDS.
KW - Respiratory distress syndrome
KW - artificial respiration
KW - covid-19
KW - intensive care units
KW - length of stay
KW - mechanical ventilators
KW - sars-cov-2
UR - https://www.scopus.com/pages/publications/85105389738
U2 - 10.1080/17476348.2021.1920927
DO - 10.1080/17476348.2021.1920927
M3 - Journal article
C2 - 33882768
SN - 1747-6348
VL - 15
SP - 1347
EP - 1354
JO - Expert Review of Respiratory Medicine
JF - Expert Review of Respiratory Medicine
IS - 10
ER -