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Region Hovedstaden - en del af Københavns Universitetshospital
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Outcomes Following Pouch Formation in Paediatric Ulcerative Colitis: A Study from the Porto Group of ESPGHAN

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  3. Does infliximab prevent colectomy in acute and chronic active ulcerative colitis?

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  • Esther Orlanski-Meyer
  • Chani Topf-Olivestone
  • Oren Ledder
  • Iris Dotan
  • Lars Folmer-Hansen
  • Angelika Kindermann
  • Amit Assa
  • Kaija-Leena Kolho
  • Sanja Kolaček
  • Matthew W Carroll
  • Caterina Strisciuglio
  • Marina Aloi
  • Richard Hansen
  • Dan Navon
  • Harland S Winter
  • Victor Manuel Navas-López
  • Lissy de Ridder
  • Françoise Smets
  • Batia Weiss
  • Dan Turner
Vis graf over relationer

INTRODUCTION: Contemporary pediatric data on pouch outcomes are sparse, especially in the era of laparoscopic surgeries. We aimed to assess outcomes and predictors in children with ulcerative colitis/inflammatory bowel disease (IBD)-unclassified who underwent colectomy and ileal pouch-anal anastomosis. METHODS: This was a multicenter retrospective cohort study from 17 IBD centers affiliated with the pediatric IBD Porto group of ESPGHAN. An electronic REDcap system was used to collate baseline characteristics, demographic, clinical, management and surgical data, short- and long-term outcomes, and to identify potential predictors of pouch outcome. RESULTS: Of the 129 patients included, 86 (67%) developed pouchitis during follow-up of median 40 months (interquartile range 26-72), of whom 33 (26%) with chronic pouchitis. Patients operated on by surgeons performing <10 pouch surgeries/year had a higher rate of chronic pouchitis (11/27 [41%] vs 8/54 [15%], P = 0.013) on both univariable and multivariable analyses and also associated with time to pouchitis (P = 0.018) and chronic pouchitis (P = 0.020). At last follow-up, overall pouch performance was rated good/excellent in 86 (74%) patients. Time from colectomy to pouch formation was not associated with pouch outcomes. Despite higher rate of nonsevere surgical complications among children undergoing colectomy at <10 years of age (7/16 [44%] vs 10/92 [11%], P = 0.003), functional outcome and pouchitis rate did not differ. CONCLUSIONS: Pouchitis rate in children with ulcerative colitis/IBD unclassified is high. Surgeon experience is the major modifiable risk factor for pouch outcome. Our analyses suggest that pouch surgery can also be performed successfully in young children.

OriginalsprogEngelsk
TidsskriftJournal of Pediatric Gastroenterology and Nutrition
Vol/bind71
Udgave nummer3
Sider (fra-til)346-353
Antal sider8
ISSN0277-2116
DOI
StatusUdgivet - 1 sep. 2020

ID: 60095773