Outcomes After Transcatheter Mitral Valve Replacement According to Regurgitation Etiology

Nils Perrin; Walid Ben Ali; Sebastian Ludwig; Alison Duncan; Jessica Weimann; Georg Nickenig; Tetsu Tanaka; Augustin Coisne; Andre Vincentelli; Raj Makkar; John G Webb; Mariama Akodad; David W M Muller; Paul Jansz; Fabien Praz; David Reineke; Mirjam G Wild; Jörg Hausleiter; Sachin S Goel; Paolo Denti; Omar Chehab; Gry Dahle; Stephan Baldus; Hendrik Ruge; Tsuyoshi Kaneko; Julien Ternacle; Nicolas Dumonteil; Ralph Stephan von Bardeleben; Michele Flagiello; Thomas Walther; Maurizio Taramasso; Lars Søndergaard; Sabine Bleiziffer; Neil Fam; Joerg Kempfert; Juan F Granada; Gilbert H L Tang; Lenard Conradi; Thomas Modine; CHOICE-MI Investigators

doi:10.1016/j.athoracsur.2023.08.033

Outcomes After Transcatheter Mitral Valve Replacement According to Regurgitation Etiology

Nils Perrin^*, Walid Ben Ali, Sebastian Ludwig, Alison Duncan, Jessica Weimann, Georg Nickenig, Tetsu Tanaka, Augustin Coisne, Andre Vincentelli, Raj Makkar, John G Webb, Mariama Akodad, David W M Muller, Paul Jansz, Fabien Praz, David Reineke, Mirjam G Wild, Jörg Hausleiter, Sachin S Goel, Paolo DentiOmar Chehab, Gry Dahle, Stephan Baldus, Hendrik Ruge, Tsuyoshi Kaneko, Julien Ternacle, Nicolas Dumonteil, Ralph Stephan von Bardeleben, Michele Flagiello, Thomas Walther, Maurizio Taramasso, Lars Søndergaard, Sabine Bleiziffer, Neil Fam, Joerg Kempfert, Juan F Granada, Gilbert H L Tang, Lenard Conradi, Thomas Modine, CHOICE-MI Investigators

^*Corresponding author af dette arbejde

Afdeling for Hjertesygdomme

Abstract

BACKGROUND: Whether transcatheter mitral valve replacement (TMVR) devices perform similarly with respect to the underlying mitral regurgitation (MR) etiology remains unknown. The aim of the present analysis was to assess outcomes of TMVR according to the MR underlying etiology among the CHoice of OptImal transCatheter trEatment for Mitral Insufficiency (CHOICE-MI) registry.

METHODS: Of 746 patients, 229 patients (30.7%) underwent TMVR. The study population was subdivided according to primary, secondary, or mixed MR. Patients with mitral annular calcification were excluded. The primary study endpoint was a composite endpoint of all-cause mortality or hospitalization for heart failure at 1 year. Secondary study endpoints were all-cause and cardiovascular mortality at 1 year, New York Heart Association functional class, and residual MR, both at discharge and 1 year.

RESULTS: The predominant MR etiology was secondary MR (58.4%), followed by primary MR (28.7%) and mixed MR (12.9%). Technical success and procedural mortality were similar according to MR etiology. Discharge echocardiography revealed residual MR 2+ in 11.3%, 3.7%, and 5.3% of patients with primary, secondary, and mixed MR, respectively (P = .1). MR elimination was similar in all groups up to the 1-year follow-up. There was no difference in terms of primary combined outcome occurrence according to MR etiology. One-year all-cause mortality was reported in 28.8%, 24.2%, and 32.1% of patients with primary, secondary, and mixed MR, respectively (P = .07).

CONCLUSIONS: In our study we did not find differences in short-term and 1-year outcomes after TMVR according to MR etiology.

Originalsprog	Engelsk
Tidsskrift	The Annals of thoracic surgery
Vol/bind	117
Udgave nummer	5
Sider (fra-til)	958-964
Antal sider	7
ISSN	0003-4975
DOI	https://doi.org/10.1016/j.athoracsur.2023.08.033
Status	Udgivet - 2024

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10.1016/j.athoracsur.2023.08.033

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Perrin, N., Ben Ali, W., Ludwig, S., Duncan, A., Weimann, J., Nickenig, G., Tanaka, T., Coisne, A., Vincentelli, A., Makkar, R., Webb, J. G., Akodad, M., Muller, D. W. M., Jansz, P., Praz, F., Reineke, D., Wild, M. G., Hausleiter, J., Goel, S. S., ... CHOICE-MI Investigators (2024). Outcomes After Transcatheter Mitral Valve Replacement According to Regurgitation Etiology. The Annals of thoracic surgery, 117(5), 958-964. https://doi.org/10.1016/j.athoracsur.2023.08.033

Perrin, N, Ben Ali, W, Ludwig, S, Duncan, A, Weimann, J, Nickenig, G, Tanaka, T, Coisne, A, Vincentelli, A, Makkar, R, Webb, JG, Akodad, M, Muller, DWM, Jansz, P, Praz, F, Reineke, D, Wild, MG, Hausleiter, J, Goel, SS, Denti, P, Chehab, O, Dahle, G, Baldus, S, Ruge, H, Kaneko, T, Ternacle, J, Dumonteil, N, Stephan von Bardeleben, R, Flagiello, M, Walther, T, Taramasso, M, Søndergaard, L, Bleiziffer, S, Fam, N, Kempfert, J, Granada, JF, Tang, GHL, Conradi, L, Modine, T & CHOICE-MI Investigators 2024, 'Outcomes After Transcatheter Mitral Valve Replacement According to Regurgitation Etiology', The Annals of thoracic surgery, bind 117, nr. 5, s. 958-964. https://doi.org/10.1016/j.athoracsur.2023.08.033

@article{e314e97b41b54ab994546a645e838eed,

title = "Outcomes After Transcatheter Mitral Valve Replacement According to Regurgitation Etiology",

abstract = "BACKGROUND: Whether transcatheter mitral valve replacement (TMVR) devices perform similarly with respect to the underlying mitral regurgitation (MR) etiology remains unknown. The aim of the present analysis was to assess outcomes of TMVR according to the MR underlying etiology among the CHoice of OptImal transCatheter trEatment for Mitral Insufficiency (CHOICE-MI) registry.METHODS: Of 746 patients, 229 patients (30.7%) underwent TMVR. The study population was subdivided according to primary, secondary, or mixed MR. Patients with mitral annular calcification were excluded. The primary study endpoint was a composite endpoint of all-cause mortality or hospitalization for heart failure at 1 year. Secondary study endpoints were all-cause and cardiovascular mortality at 1 year, New York Heart Association functional class, and residual MR, both at discharge and 1 year.RESULTS: The predominant MR etiology was secondary MR (58.4%), followed by primary MR (28.7%) and mixed MR (12.9%). Technical success and procedural mortality were similar according to MR etiology. Discharge echocardiography revealed residual MR 2+ in 11.3%, 3.7%, and 5.3% of patients with primary, secondary, and mixed MR, respectively (P = .1). MR elimination was similar in all groups up to the 1-year follow-up. There was no difference in terms of primary combined outcome occurrence according to MR etiology. One-year all-cause mortality was reported in 28.8%, 24.2%, and 32.1% of patients with primary, secondary, and mixed MR, respectively (P = .07).CONCLUSIONS: In our study we did not find differences in short-term and 1-year outcomes after TMVR according to MR etiology.",

keywords = "Aged, Aged, 80 and over, Cardiac Catheterization/methods, Female, Follow-Up Studies, Heart Valve Prosthesis Implantation/methods, Humans, Male, Middle Aged, Mitral Valve Insufficiency/surgery, Mitral Valve/surgery, Registries, Retrospective Studies, Treatment Outcome",

author = "Nils Perrin and {Ben Ali}, Walid and Sebastian Ludwig and Alison Duncan and Jessica Weimann and Georg Nickenig and Tetsu Tanaka and Augustin Coisne and Andre Vincentelli and Raj Makkar and Webb, {John G} and Mariama Akodad and Muller, {David W M} and Paul Jansz and Fabien Praz and David Reineke and Wild, {Mirjam G} and J{\"o}rg Hausleiter and Goel, {Sachin S} and Paolo Denti and Omar Chehab and Gry Dahle and Stephan Baldus and Hendrik Ruge and Tsuyoshi Kaneko and Julien Ternacle and Nicolas Dumonteil and {Stephan von Bardeleben}, Ralph and Michele Flagiello and Thomas Walther and Maurizio Taramasso and Lars S{\o}ndergaard and Sabine Bleiziffer and Neil Fam and Joerg Kempfert and Granada, {Juan F} and Tang, {Gilbert H L} and Lenard Conradi and Thomas Modine and {CHOICE-MI Investigators}",

note = "Copyright {\textcopyright} 2023. Published by Elsevier Inc.",

year = "2024",

doi = "10.1016/j.athoracsur.2023.08.033",

language = "English",

volume = "117",

pages = "958--964",

journal = "The Annals of thoracic surgery",

issn = "0003-4975",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Outcomes After Transcatheter Mitral Valve Replacement According to Regurgitation Etiology

AU - Perrin, Nils

AU - Ben Ali, Walid

AU - Ludwig, Sebastian

AU - Duncan, Alison

AU - Weimann, Jessica

AU - Nickenig, Georg

AU - Tanaka, Tetsu

AU - Coisne, Augustin

AU - Vincentelli, Andre

AU - Makkar, Raj

AU - Webb, John G

AU - Akodad, Mariama

AU - Muller, David W M

AU - Jansz, Paul

AU - Praz, Fabien

AU - Reineke, David

AU - Wild, Mirjam G

AU - Hausleiter, Jörg

AU - Goel, Sachin S

AU - Denti, Paolo

AU - Chehab, Omar

AU - Dahle, Gry

AU - Baldus, Stephan

AU - Ruge, Hendrik

AU - Kaneko, Tsuyoshi

AU - Ternacle, Julien

AU - Dumonteil, Nicolas

AU - Stephan von Bardeleben, Ralph

AU - Flagiello, Michele

AU - Walther, Thomas

AU - Taramasso, Maurizio

AU - Søndergaard, Lars

AU - Bleiziffer, Sabine

AU - Fam, Neil

AU - Kempfert, Joerg

AU - Granada, Juan F

AU - Tang, Gilbert H L

AU - Conradi, Lenard

AU - Modine, Thomas

AU - CHOICE-MI Investigators

PY - 2024

Y1 - 2024

N2 - BACKGROUND: Whether transcatheter mitral valve replacement (TMVR) devices perform similarly with respect to the underlying mitral regurgitation (MR) etiology remains unknown. The aim of the present analysis was to assess outcomes of TMVR according to the MR underlying etiology among the CHoice of OptImal transCatheter trEatment for Mitral Insufficiency (CHOICE-MI) registry.METHODS: Of 746 patients, 229 patients (30.7%) underwent TMVR. The study population was subdivided according to primary, secondary, or mixed MR. Patients with mitral annular calcification were excluded. The primary study endpoint was a composite endpoint of all-cause mortality or hospitalization for heart failure at 1 year. Secondary study endpoints were all-cause and cardiovascular mortality at 1 year, New York Heart Association functional class, and residual MR, both at discharge and 1 year.RESULTS: The predominant MR etiology was secondary MR (58.4%), followed by primary MR (28.7%) and mixed MR (12.9%). Technical success and procedural mortality were similar according to MR etiology. Discharge echocardiography revealed residual MR 2+ in 11.3%, 3.7%, and 5.3% of patients with primary, secondary, and mixed MR, respectively (P = .1). MR elimination was similar in all groups up to the 1-year follow-up. There was no difference in terms of primary combined outcome occurrence according to MR etiology. One-year all-cause mortality was reported in 28.8%, 24.2%, and 32.1% of patients with primary, secondary, and mixed MR, respectively (P = .07).CONCLUSIONS: In our study we did not find differences in short-term and 1-year outcomes after TMVR according to MR etiology.

AB - BACKGROUND: Whether transcatheter mitral valve replacement (TMVR) devices perform similarly with respect to the underlying mitral regurgitation (MR) etiology remains unknown. The aim of the present analysis was to assess outcomes of TMVR according to the MR underlying etiology among the CHoice of OptImal transCatheter trEatment for Mitral Insufficiency (CHOICE-MI) registry.METHODS: Of 746 patients, 229 patients (30.7%) underwent TMVR. The study population was subdivided according to primary, secondary, or mixed MR. Patients with mitral annular calcification were excluded. The primary study endpoint was a composite endpoint of all-cause mortality or hospitalization for heart failure at 1 year. Secondary study endpoints were all-cause and cardiovascular mortality at 1 year, New York Heart Association functional class, and residual MR, both at discharge and 1 year.RESULTS: The predominant MR etiology was secondary MR (58.4%), followed by primary MR (28.7%) and mixed MR (12.9%). Technical success and procedural mortality were similar according to MR etiology. Discharge echocardiography revealed residual MR 2+ in 11.3%, 3.7%, and 5.3% of patients with primary, secondary, and mixed MR, respectively (P = .1). MR elimination was similar in all groups up to the 1-year follow-up. There was no difference in terms of primary combined outcome occurrence according to MR etiology. One-year all-cause mortality was reported in 28.8%, 24.2%, and 32.1% of patients with primary, secondary, and mixed MR, respectively (P = .07).CONCLUSIONS: In our study we did not find differences in short-term and 1-year outcomes after TMVR according to MR etiology.

KW - Aged

KW - Aged, 80 and over

KW - Cardiac Catheterization/methods

KW - Female

KW - Follow-Up Studies

KW - Heart Valve Prosthesis Implantation/methods

KW - Humans

KW - Male

KW - Middle Aged

KW - Mitral Valve Insufficiency/surgery

KW - Mitral Valve/surgery

KW - Registries

KW - Retrospective Studies

KW - Treatment Outcome

UR - http://www.scopus.com/inward/record.url?scp=85174740234&partnerID=8YFLogxK

U2 - 10.1016/j.athoracsur.2023.08.033

DO - 10.1016/j.athoracsur.2023.08.033

M3 - Journal article

C2 - 37717882

SN - 0003-4975

VL - 117

SP - 958

EP - 964

JO - The Annals of thoracic surgery

JF - The Annals of thoracic surgery

IS - 5

ER -

Outcomes After Transcatheter Mitral Valve Replacement According to Regurgitation Etiology

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