Outcome of patients with low-gradient "severe" aortic stenosis and preserved ejection fraction

Nikolaus Jander; Jan Minners; Ingar Holme; Eva Gerdts; Kurt Boman; Philippe Brudi; John B Chambers; Kenneth Egstrup; Y Antero Kesäniemi; William Malbecq; Christoph A Nienaber; Simon Ray; Anne Rossebø; Terje Pedersen; Terje Skjærpe; Ronnie Willenheimer; Kristian Wachtell; Franz-Josef Neumann; Christa Gohlke-Bärwolf

doi:10.1161/CIRCULATIONAHA.110.983510

Outcome of patients with low-gradient "severe" aortic stenosis and preserved ejection fraction

Nikolaus Jander, Jan Minners, Ingar Holme, Eva Gerdts, Kurt Boman, Philippe Brudi, John B Chambers, Kenneth Egstrup, Y Antero Kesäniemi, William Malbecq, Christoph A Nienaber, Simon Ray, Anne Rossebø, Terje Pedersen, Terje Skjærpe, Ronnie Willenheimer, Kristian Wachtell, Franz-Josef Neumann, Christa Gohlke-Bärwolf

291 Citationer (Scopus)

Abstract

Retrospective studies have suggested that patients with a low transvalvular gradient in the presence of an aortic valve area <1.0 cm² and normal ejection fraction may represent a subgroup with an advanced stage of aortic valve disease, reduced stroke volume, and poor prognosis requiring early surgery. We therefore evaluated the outcome of patients with low-gradient "severe" stenosis (defined as aortic valve area <1.0 cm² and mean gradient ≤ 40 mm Hg) in the prospective Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study.

Originalsprog	Engelsk
Tidsskrift	Circulation (Baltimore)
Vol/bind	123
Udgave nummer	8
Sider (fra-til)	887-95
Antal sider	9
ISSN	0009-7322
DOI	https://doi.org/10.1161/CIRCULATIONAHA.110.983510
Status	Udgivet - 1 mar. 2011

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Jander, N., Minners, J., Holme, I., Gerdts, E., Boman, K., Brudi, P., Chambers, J. B., Egstrup, K., Kesäniemi, Y. A., Malbecq, W., Nienaber, C. A., Ray, S., Rossebø, A., Pedersen, T., Skjærpe, T., Willenheimer, R., Wachtell, K., Neumann, F.-J., & Gohlke-Bärwolf, C. (2011). Outcome of patients with low-gradient "severe" aortic stenosis and preserved ejection fraction. Circulation (Baltimore), 123(8), 887-95. https://doi.org/10.1161/CIRCULATIONAHA.110.983510

Jander, N, Minners, J, Holme, I, Gerdts, E, Boman, K, Brudi, P, Chambers, JB, Egstrup, K, Kesäniemi, YA, Malbecq, W, Nienaber, CA, Ray, S, Rossebø, A, Pedersen, T, Skjærpe, T, Willenheimer, R, Wachtell, K, Neumann, F-J & Gohlke-Bärwolf, C 2011, 'Outcome of patients with low-gradient "severe" aortic stenosis and preserved ejection fraction', Circulation (Baltimore), bind 123, nr. 8, s. 887-95. https://doi.org/10.1161/CIRCULATIONAHA.110.983510

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abstract = "Retrospective studies have suggested that patients with a low transvalvular gradient in the presence of an aortic valve area <1.0 cm² and normal ejection fraction may represent a subgroup with an advanced stage of aortic valve disease, reduced stroke volume, and poor prognosis requiring early surgery. We therefore evaluated the outcome of patients with low-gradient {"}severe{"} stenosis (defined as aortic valve area <1.0 cm² and mean gradient ≤ 40 mm Hg) in the prospective Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study.",

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AU - Jander, Nikolaus

AU - Minners, Jan

AU - Holme, Ingar

AU - Gerdts, Eva

AU - Boman, Kurt

AU - Brudi, Philippe

AU - Chambers, John B

AU - Egstrup, Kenneth

AU - Kesäniemi, Y Antero

AU - Malbecq, William

AU - Nienaber, Christoph A

AU - Ray, Simon

AU - Rossebø, Anne

AU - Pedersen, Terje

AU - Skjærpe, Terje

AU - Willenheimer, Ronnie

AU - Wachtell, Kristian

AU - Neumann, Franz-Josef

AU - Gohlke-Bärwolf, Christa

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AB - Retrospective studies have suggested that patients with a low transvalvular gradient in the presence of an aortic valve area <1.0 cm² and normal ejection fraction may represent a subgroup with an advanced stage of aortic valve disease, reduced stroke volume, and poor prognosis requiring early surgery. We therefore evaluated the outcome of patients with low-gradient "severe" stenosis (defined as aortic valve area <1.0 cm² and mean gradient ≤ 40 mm Hg) in the prospective Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study.

UR - https://www.scopus.com/pages/publications/79952453659

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M3 - Journal article

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JO - Circulation (Baltimore)

JF - Circulation (Baltimore)

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Outcome of patients with low-gradient "severe" aortic stenosis and preserved ejection fraction

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