Outcome of patients with low-gradient "severe" aortic stenosis and preserved ejection fraction

Nikolaus Jander, Jan Minners, Ingar Holme, Eva Gerdts, Kurt Boman, Philippe Brudi, John B Chambers, Kenneth Egstrup, Y Antero Kesäniemi, William Malbecq, Christoph A Nienaber, Simon Ray, Anne Rossebø, Terje Pedersen, Terje Skjærpe, Ronnie Willenheimer, Kristian Wachtell, Franz-Josef Neumann, Christa Gohlke-Bärwolf

    282 Citationer (Scopus)

    Abstract

    Retrospective studies have suggested that patients with a low transvalvular gradient in the presence of an aortic valve area <1.0 cm² and normal ejection fraction may represent a subgroup with an advanced stage of aortic valve disease, reduced stroke volume, and poor prognosis requiring early surgery. We therefore evaluated the outcome of patients with low-gradient "severe" stenosis (defined as aortic valve area <1.0 cm² and mean gradient ≤ 40 mm Hg) in the prospective Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study.
    OriginalsprogEngelsk
    TidsskriftCirculation (Baltimore)
    Vol/bind123
    Udgave nummer8
    Sider (fra-til)887-95
    Antal sider9
    ISSN0009-7322
    DOI
    StatusUdgivet - 1 mar. 2011

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