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Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer

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@article{0ef20427daff4510b0896b1f979e7970,
title = "Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer",
abstract = "BACKGROUND: Isolated regional recurrences following head-neck squamous-cell carcinomas (HNSCC) are often accessible for curatively intended salvage treatment. Factors prognostic for outcome were investigated in a large cohort of HNSCC patients.METHODS: In total, 1811 patients receiving curatively intended radiotherapy from 2007 to 2017 were reviewed and isolated cervical nodal recurrences were identified. Factors associated with survival and second recurrence were investigated using univariate and multivariate analyses.RESULTS: Isolated regional recurrence was seen in 95/1811 (5.2%) patients. Eighty of 95 patients (84%) received salvage surgery. Two-year survival after isolated regional recurrence was 40%. Overall survival (OS) and time to second recurrence were associated with resection status of the salvage surgery and presence of extranodal spread (ENS), while p16-positive oropharyngeal squamous-cell carcinoma (OPSCC) was associated with better OS.CONCLUSION: Long-term survival after regional recurrence in HNSCC is possible. p16-positive OPSCC, complete salvage surgery, and lack of ENS are associated with better outcome.",
keywords = "head and neck cancer, prognostic factors, recurrence, salvage treatment, survival",
author = "Lindegaard, {Anne Marie} and {von Buchwald}, Christian and Rasmussen, {Jacob H} and Lena Specht and Vogelius, {Ivan R} and Martin Zamani and Woller, {Nina Claire} and Giedrius Lelkaitis and Jeppe Friborg",
note = "{\textcopyright} 2020 Wiley Periodicals LLC.",
year = "2020",
month = nov,
day = "1",
doi = "10.1002/hed.26361",
language = "English",
volume = "42",
pages = "3161--3170",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "11",

}

RIS

TY - JOUR

T1 - Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer

AU - Lindegaard, Anne Marie

AU - von Buchwald, Christian

AU - Rasmussen, Jacob H

AU - Specht, Lena

AU - Vogelius, Ivan R

AU - Zamani, Martin

AU - Woller, Nina Claire

AU - Lelkaitis, Giedrius

AU - Friborg, Jeppe

N1 - © 2020 Wiley Periodicals LLC.

PY - 2020/11/1

Y1 - 2020/11/1

N2 - BACKGROUND: Isolated regional recurrences following head-neck squamous-cell carcinomas (HNSCC) are often accessible for curatively intended salvage treatment. Factors prognostic for outcome were investigated in a large cohort of HNSCC patients.METHODS: In total, 1811 patients receiving curatively intended radiotherapy from 2007 to 2017 were reviewed and isolated cervical nodal recurrences were identified. Factors associated with survival and second recurrence were investigated using univariate and multivariate analyses.RESULTS: Isolated regional recurrence was seen in 95/1811 (5.2%) patients. Eighty of 95 patients (84%) received salvage surgery. Two-year survival after isolated regional recurrence was 40%. Overall survival (OS) and time to second recurrence were associated with resection status of the salvage surgery and presence of extranodal spread (ENS), while p16-positive oropharyngeal squamous-cell carcinoma (OPSCC) was associated with better OS.CONCLUSION: Long-term survival after regional recurrence in HNSCC is possible. p16-positive OPSCC, complete salvage surgery, and lack of ENS are associated with better outcome.

AB - BACKGROUND: Isolated regional recurrences following head-neck squamous-cell carcinomas (HNSCC) are often accessible for curatively intended salvage treatment. Factors prognostic for outcome were investigated in a large cohort of HNSCC patients.METHODS: In total, 1811 patients receiving curatively intended radiotherapy from 2007 to 2017 were reviewed and isolated cervical nodal recurrences were identified. Factors associated with survival and second recurrence were investigated using univariate and multivariate analyses.RESULTS: Isolated regional recurrence was seen in 95/1811 (5.2%) patients. Eighty of 95 patients (84%) received salvage surgery. Two-year survival after isolated regional recurrence was 40%. Overall survival (OS) and time to second recurrence were associated with resection status of the salvage surgery and presence of extranodal spread (ENS), while p16-positive oropharyngeal squamous-cell carcinoma (OPSCC) was associated with better OS.CONCLUSION: Long-term survival after regional recurrence in HNSCC is possible. p16-positive OPSCC, complete salvage surgery, and lack of ENS are associated with better outcome.

KW - head and neck cancer

KW - prognostic factors

KW - recurrence

KW - salvage treatment

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=85087936087&partnerID=8YFLogxK

U2 - 10.1002/hed.26361

DO - 10.1002/hed.26361

M3 - Journal article

C2 - 32681703

VL - 42

SP - 3161

EP - 3170

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 11

ER -

ID: 60986039